List of Famous people born in Sicily, Italy

Gianfranco Miccichè is an Italian politician.

Margareth Madè born Margareth Tamara Maccarrone is an Italian model and actress. She uses her artist name because her own surname "Maccarrone" has too many associations with pasta.

Calogero Alessandro Augusto Calà, known by his stage name Jerry Calà, is an Italian actor, filmmaker, comedian and singer who has written, directed, and acted in multiple film and television projects. He is considered one of the most popular Italian comedians of the eighties and nineties in his country.

Napoleone Ferrara, is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a career in Northern California at the biotechnology giant Genentech, where he pioneered the development of new treatments for angiogenic diseases such as cancer, age-related macular degeneration (AMD), and diabetic retinopathy. At Genentech, he discovered VEGF—and made the first anti-VEGF antibody—which suppresses growth of a variety of tumors. These findings helped lead to development of the first clinically available angiogenesis inhibitor, bevacizumab (Avastin), which prevents the growth of new blood vessels into a solid tumor and which has become part of standard treatment for a variety of cancers. Ferrara's work led also to the development of ranibizumab (Lucentis), a drug that is highly effective at preventing vision loss in intraocular neovascular disorders.

Donatella Finocchiaro is an Italian actress. She has appeared in more than 20 films since 2002. She starred in The Wedding Director, which was screened in the Un Certain Regard section at the 2006 Cannes Film Festival.

Carlo Vizzini is an Italian politician.

Leoluca Orlando, is an Italian politician, current Mayor of Palermo. He was also mayor of the city in 1985–1990 and 1993–2000 and President of Italian Federation of American Football (FIDAF). He is best known for his strong opposition to the Sicilian Mafia during his mayoralty in the 1980s, which was publicly referenced in the media as the "Palermo Spring".