List of Famous people born in Santiago Metropolitan Region, Chile

Karol Aída Cariola Oliva is a Chilean politician, and former president of the Federación de Estudiantes de la Universidad de Concepción for 2010. She was elected General Secretary of the Juventudes Comunistas de Chile, abbr. JJ.CC., at the organizations XIII Congress held in October 2011. Cariola is the second woman to hold this post in the Communist Youth of Chile after the late communist leader Gladys Marin (1941-2005).

Érika Alejandra Olivera de la Fuente is a female marathon runner from Chile and deputy for the National Renewal party. She has competed at five Olympic Games, the most Olympic appearances ever by a female marathon runner.

Alejandro Eduardo Goic Jerez is a Chilean actor. He appeared in more than fifty films since 1988.

Ricardo Froilán Lagos Escobar is a Chilean lawyer, economist and social-democratic politician who served as President of Chile from 2000 to 2006. He won the 1999-2000 presidential election by a narrow margin in a runoff over Independent Democrat Union (UDI) candidate Joaquín Lavín. Lagos was the third president from the center-left Coalition of Parties for Democracy to have ruled Chile since 1990. He was succeeded on March 11, 2006 by Socialist Michelle Bachelet, from the same coalition. Since May 2007 he has served as a Special Envoy on Climate Change for the United Nations Secretary-General Ban Ki-moon.

Laurence Nelson Golborne Riveros is a Chilean engineer and entrepreneur. He was minister of public works until November 7, 2012, when he announced his decision to run for President of Chile. He previously had been bi-minister of Mining and Energy in the administration of President Sebastián Piñera. He withdrew from the presidential campaign on April 29, 2013, after two consecutive public scandals.

Álex Anwandter Donoso is a Chilean singer-songwriter, musician, and film and music video director. He became popular as the vocalist for the band Teleradio Donoso (2005–2009). In 2010, he began work as a soloist. Anwandter has two nominations for the Latin Grammy for Best New Artist and Best Short Form Music Video.

Alejandro Navarro Brain is a Chilean politician who has served as a member of Parliament for the Bío-Bío Region since 1994. First as Deputy and since 2006 as Senator, in 2009 founded the Broad Social Movement, same year that he ran for the President of the Republic post. His partner is Ana Garcia Sciaraffia and has five children. He later left MAS to form País.

José Luis Villanueva Ahumada is a Chilean former footballer. His last squad was Deportes Magallanes.

Oscar Castro Ramírez,, was a Chilean playwright, actor and director of the Aleph Theater.

Fernando José Paulsen Silva is a Chilean radio journalist, television presenter, columnist, sports and political commentator.