List of Famous people born in Santiago Metropolitan Region, Chile

Hans Podlipnik Castillo is a Chilean retired tennis player of Slovenian descent. His best results are in doubles, winning one ATP World Tour and reaching another final in this category, besides from winning 19 Challengers and 29 Futures. In singles, he won 23 Futures and reaching in 2015 the final in the Poprad-Tatry Challenger.

Eliseo Salazar Valenzuela is a Chilean former racing driver. As of December 2020, he is the only Chilean to have participated in a Formula One World Championship. He made his Formula One debut on 15 March 1981, and ultimately contested 37 races scoring a total of three championship points. After Formula One, Salazar has participated in numerous motorsport disciplines, including the Chilean national rally championship, Formula 3000, IndyCar, and the World Sportscar Championship.

Héctor Morales is a Chilean actor. He appeared in more than twenty films since 2004. Morales is best known for his performance as Goyo in the 2008 film Tony Manero

Isabel San Sebastián Cabasés is a Spanish journalist and writer.

Carlos Alonso Enrique Palacios Núñez is a Chilean footballer who plays as a forward or attacking midfielder for Brazilian club Internacional de Porto Alegre on loan from Unión Española.

Katarzyna Helena Kowałeczko Henríquez, better known as Katty Kowaleczko or Katty Ko, is a Chilean actress of Polish ancestry.

Andrea Marisa Victoria Tessa Vergara is a Chilean singer-songwriter, TV presenter, and actress of Italian descent. Daughter of the operatic soprano Victoria Vergara Olguín and Patricio Tessa Marchant. She studied at Scuola Italiana de Santiago.

Francisca Mardones is a Chilean wheelchair tennis player. She has competed at both the 2012 and 2016 Summer Paralympics in tennis, before retiring in 2017 to concentrate on athletics.

Evelyn Rose Matthei Fornet is a Chilean politician who served as Minister of Labor and Social Security under Chilean President Sebastián Piñera until July 2013. She was the Independent Democrat Union Party's nominee for President of Chile in the 2013 elections. Today she is the mayor of Providencia, her term being 2016-2020.

Rafael Luis Araneda Maturana is a popular Chilean TV presenter, best known for his participation in the show Rojo Fama Contrafama as the host. Also he was the host of Estrellas en el Hielo, Sin Prejuicios, Rojo VIP, Noche de Juegos, El Baile en TVN. Rafael Araneda is married to the hostess Marcela Vacarezza Etcheverry and they have three children, Martina, Florencia and Vicente.