List of Famous people born in Santiago Metropolitan Region, Chile

Pablo Mackenna Dörr, is a Chilean television presenter, writer and poet. He was a host of the Chilean version of television show CQC.

María Ignacia Allamand Lyon is a Chilean film and television actress.

Colombina Violeta Parra Tuca is a Chilean musician and singer. She was part of the Chilean grunge/alternative rock scene in the 1990s. Her band, Ex, were well known in Latin America when their first album came out with singles like "Sacar la Basura", "La Corbata de mi Tío" and "Vendo Diario" in 1996.

Javiera Diaz de Valdés Alemparte, is a Chilean television actress best known for her role in the telenovela "Gatas y Tuercas". Javiera is a descendant of Javiera Carrera, a Chilean patriot of Basque descent, married to Spanish Pedro Díaz de Valdés.

Pamela Andrea Díaz Saldías, also known as "La Fiera", is a Chilean model and media celebrity who is active in Chilean show business.

Javier Leopoldo Roca Sepúlveda is a Chilean professional football coach and former player who is currently head coach of Liga 1 club Persik Kediri.

María Cecilia Morel Montes is the wife of the President of Chile Sebastián Piñera, and as such is the First Lady of Chile; she is also the Sociocultural Area Director of the Presidency, for her husband's presidency (2010–2014).

Silvia Beatriz Guazzini Monsalve, best known as Coca Guazzini, is a Chilean television, theatre and film actress. Guazzini studied theatre at Universidad de Chile. She appeared in some popular Chilean telenovelas like Sucupira, Aquelarre and Tic-Tac. In 2002 Coca Guazzini won the Apes Award for "Best Actress".

María Francisca Gavilán Valladares is a Chilean film, theater, and television actress and singer.

Paulina Marcela Urrutia Fernández is a Chilean actress, academic, director, trade union leader, and politician. She was a State Minister of the first government of President Michelle Bachelet.