List of Famous people born in Santiago Metropolitan Region, Chile

Alejandro Gastón Aravena Mori is a Chilean architect and executive director of the firm Elemental S.A. He won the Pritzker Architecture Prize in 2016, and also, he was the director and curator of the Architecture Section of the 2016 Venice Biennale.

María José Zaldívar Larraín is a Chilean lawyer and politician who currently serves as the Minister of Labour and Social Welfare in the second government of Sebastián Piñera.

Mauricio José Rojas Mullor is a Chilean-Swedish politician and political economist, member of the Riksdag between 2002 and 2006. He served as Minister of Cultures, Arts and Heritage of Chile for four days, since August 10 2018 until August 13, under the presidency of Sebastián Piñera.

Tamara Olga Acosta Zambra is a prominent Chilean actress.

Carmen Gloria Quintana Arancibia is a Chilean woman who suffered severe burns in an incident where she and other young people were detained by an army patrol during a street demonstration against the dictatorship of Augusto Pinochet. She survived, and thereafter became a symbol of hope for democracy in Chile to many, receiving an embrace and encouragement from Pope John Paul II.

Anita Ester Alvarado Muñoz, better known as "The Chilean Geisha" and Anita Alvarado was involved in one of the largest financial frauds carried out in Japan where she worked as a prostitute. On her return to Chile, she pursued a career in show business, as an actress and singer, and being a frequent guest on reality television programmes.

Igor Lichnovsky Osorio is a Chilean professional footballer who plays for Saudi Arabian club Al Shabab FC and the Chile national team as a central defender.

José Ignacio Valenzuela also known by the nickname Chascas, is a Chilean writer and screenwriter. Author of scripts for national and foreign soap operas, among which Amor a domicilio, La familia de al lado, Dama y obrero and adaptation of Lola—, He has also participated in the development of various television, literature, film and theater projects in Chile, Mexico, United States and Puerto Rico. He has published a number of novels and short fiction, and has also served as professor and instructor of creative writing.

Cristián de la Fuente is a Chilean–American actor, presenter, model and producer.

Francisco Anderson Huaiquipán Castillo is a former Chilean footballer.