List of Famous people born in Castile and León, Spain

Anne of Austria, a Spanish princess and an Austrian archduchess of the House of Habsburg, was queen of France as the wife of Louis XIII, and powerful regent of France during the minority of her son, Louis XIV, from 1643 to 1651. During her regency, Cardinal Mazarin served as France's chief minister. Accounts of French court life of her era emphasize her difficult marital relations with her husband, her closeness to her son Louis XIV, and her disapproval of her son's marital infidelity to her niece and daughter-in-law Maria Theresa.

Ramiro Ledesma Ramos was a Spanish philosopher, politician, writer, essayist, and journalist, known as one of the pioneers in the introduction of Fascism in Spain.

Diego Rico Salguero is a Spanish professional footballer who plays as a left back for Real Sociedad.

María Margarita Robles Fernández is a Spanish judge and politician, currently serving as Minister of Defence since June 2018. From November 2019 to January 2020, she served as Acting Minister of Foreign Affairs.

Vicente del Bosque González, 1st Marquess of Del Bosque is a Spanish football manager and former player who last managed the Spain national team. He is regarded as one of the greatest and most successful managers of all time; he is to date the only football manager to have won the Champions League, the European Championship, and the World Cup, as well as the Intercontinental Cup.

Félix Samuel Rodríguez de la Fuente was a Spanish naturalist and broadcaster. He is best known for the highly successful and influential TV series, El Hombre y la Tierra (1974–1980). A graduate in medicine and self-taught in biology, he was a multifaceted charismatic figure whose influence has endured despite the passing years.

José Buenaventura Durruti Dumange was a Spanish insurrectionary, anarcho-syndicalist militant involved with the CNT, FAI and other anarchist organisations during the period leading up to and including the Spanish Civil War. Durruti played an influential role during the Spanish Revolution and is remembered as a hero in the anarchist movement.

José Luis Rodríguez Zapatero is a Spanish politician and member of the Spanish Socialist Workers' Party (PSOE). He was the Prime Minister of Spain being elected for two terms, in the 2004 and 2008 general elections. On 2 April 2011 he announced he would not stand for re-election in the 2011 general election and left office on 21 December 2011.

Gonzalo Queipo de Llano y Sierra was a Spanish military leader who rose to prominence during the July 1936 coup d'état and the subsequent Spanish Civil War and White Terror.

Eleuterio Sánchez Rodríguez, known as El Lute, was at one time listed as Spain's "Most Wanted" criminal and later became a published writer. He was a legendary Spanish outlaw who escaped several times from prison after being convicted of murder and sentenced at age 23 to 30 years. While in prison, he learned to read, earned a law degree, and became a writer, continuing to protest his innocence of the charges. He was pardoned and released on June 20, 1981, at the age of 39.