List of Famous people born in Guantánamo Province, Cuba

Frank Sánchez Faure is a Cuban professional boxer who has held the NABO heavyweight title since 2019 and the WBC Continental Americas heavyweight title since 2020.

Yuriorkis Gamboa Toledano is a Cuban professional boxer. He is a former unified featherweight world champion, having held the WBA and IBF titles between 2009 and 2011, as well as the WBA interim championship in both the super featherweight and lightweight divisions. As an amateur he won a gold medal in the flyweight division at the 2004 Olympics, and bronze in the featherweight division at the 2005 World Championships.

Olga Merediz is an American actress. Merediz originated the role of Abuela Claudia in the Broadway musical In the Heights, for which she received a Tony nomination for Best Performance by a Featured Actress in a Musical. She played the role for the show's entire Broadway run, and will reprise the role in the film adaptation. Her television credits include NBC's 2016 series Shades of Blue and Netflix's Orange Is the New Black.

Yurisbel Gracial Garcia is a Cuban baseball player. He plays for the Fukuoka SoftBank Hawks of Nippon Professional Baseball (NPB).

Erislandy Lara Santoya is a Cuban-American professional boxer who has held the WBA (Regular) light middleweight title since 2019. Previously, he held the WBA light middleweight title from 2014 to 2018, and the IBO light middleweight title from 2015 to 2018. As of September 2019, he is ranked as the world's second best active light middleweight by BoxRec, third by The Ring magazine and fifth by the Transnational Boxing Rankings Board.

Onelki García is a Cuban professional baseball pitcher for the CTBC Brothers of the Chinese Professional Baseball League (CPBL). He has played in Major League Baseball (MLB) for the Los Angeles Dodgers and Kansas City Royals, and in Nippon Professional Baseball (NPB) for the Chunichi Dragons and Hanshin Tigers.

José Legrá is a retired professional featherweight boxer. He is a former two time WBC World Featherweight Champion.

Yargelis Savigne Herrera is a Cuban athlete competing in the triple jump and long jump.

Arlen López Cardona is a Cuban boxer. He won the gold medal in the men's middleweight event at the 2016 Summer Olympics. Five years later, he won the gold medal in the men's light heavyweight event at the 2020 Summer Olympics, defeating Benjamin Whittaker.

Arnaldo Tamayo Méndez is a Cuban military officer, legislator, and former cosmonaut and the first person of African heritage in space. As a member of the crew of Soyuz 38, he became the first Cuban citizen, the first Latin American, the first person of African descent, and the first person from a country in the Western Hemisphere other than the United States to travel into Earth orbit.