List of Famous people born in Castile-La Mancha, Spain

Andrés Hurtado de Mendoza y Cabrera, 3rd Marquis of Cañete was a Spanish military officer and, from June 29, 1556 to his death on March 30, 1561, the fifth Viceroy of Peru.

Diego López de Pacheco was a Spanish noble, 2nd Duke of Escalona and 2nd Marquis of Villena.

Miguel Ángel Guerrero Martín is a Spanish professional footballer who plays for Rayo Vallecano as a forward.

Esther Cañadas is a Spanish model and actress.

Cristina García Rodero is a Spanish photographer and member of Magnum Photos and Agence Vu photo agencies.

Galswintha (540–568) was a queen consort of Neustria. She was the daughter of Athanagild, Visigothic king of Hispania, and Goiswintha. Galswintha was the sister of Brunhilda, Queen of Austrasia; and the wife of Chilperic I, the Merovingian king of Neustria. Galswintha was likely murdered at the urging of Chilperic's former concubine Fredegund, instigating a 40 year civil war within the Merovingian kingdom.

Sergio Gutiérrez Prieto is a Spanish politician of the Spanish Socialist Workers Party serving as Member of the Congress of Deputies since 2019. He also chairs the Committee on Foreign Affairs. Previously, he has served as a Member of the European Parliament from 2010 to 2019.

Mabel Lozano is a Spanish writer, model, film director, film and television actress and activist in defense of women's rights. In her work she denounces the sexual exploitation of women through prostitution and trafficking. In 2021 she received the Goya Award for best documentary short film for Biografía del cadáver de una mujer.