List of Famous people born in Castile-La Mancha, Spain

María Teresa de Borbón y Vallabriga, 15th Countess of Chinchón, was a Spanish noblewoman and grandee. She was a patrilineal granddaughter of Philip V of Spain.

Pedro González de Mendoza was a Spanish cardinal and statesman who served as Archbishop of Toledo (1482–1495), Archbishop of Sevilla (1474–1482), Bishop of Sigüenza (1467–1474), and Bishop of Calahorra y La Calzada (1453–1467).

Catherine of Castile was suo jure Princess of Asturias and heiress presumptive to the Castilian throne all her life.

Luis Hurtado de Mendoza y Pacheco, 2nd Marquess of Mondéjar was a Spanish nobleman.

Don Mercurio Antonio López Pacheco y Portugal Acuña Manrique Silva Girón y Portocarrero, twice Grandee of Spain, 9th Duke of Escalona, 9th Marquis of Villena, 15th Count of Castañeda, 11th Count of San Esteban de Gormaz and 9th Count of Xiquena, was a Spanish aristocrat and academician.

José Herrada Lopez is a Spanish professional road bicycle racer, who currently rides for UCI WorldTeam Cofidis. His brother Jesús Herrada is also a professional cyclist, and also competes for Cofidis.

Francisco "Fran" José Sandaza Asensio is a Spanish professional footballer who plays as a striker for Indian Super League club Hyderabad FC.

José Salcedo Palomeque was a Spanish film editor with over 120 feature film credits. He had an extended collaboration with the director Pedro Almodóvar, having edited all of Almodóvar's films from 1980 until his death. Almodóvar himself has been called Spain's "most famous director since Luis Buñuel."