List of Famous people born in Owensboro, United States of America

John Christopher Depp II is an American actor, producer, and musician. He has been nominated for ten Golden Globe Awards, winning one for Best Actor for his performance of the title role in Sweeney Todd: The Demon Barber of Fleet Street (2007), and has been nominated for three Academy Awards for Best Actor, among other accolades. Depp made his film debut in the 1984 film A Nightmare on Elm Street, before rising to prominence as a teen idol on the television series 21 Jump Street (1987–1990). He had a supporting role in Oliver Stone's 1986 war film Platoon and played the title character in the 1990 romantic fantasy Edward Scissorhands.

Nicholas Patrick Hayden, nicknamed "The Kentucky Kid", was an American professional motorcycle racer who won the MotoGP World Championship in 2006. Hayden began racing motorcycles at a young age. He began his road racing career in the CMRA before progressing to the AMA Supersport Championship and then to the AMA Superbike Championship. He won the AMA title in 2002 and was approached by the Repsol Honda team to race for them in MotoGP.

Kevin Oluwole Olusola is an American musician, beatboxer, cellist, rapper, record producer, singer, and songwriter. Olusola is best known as the beatboxer of the a capella band Pentatonix. After the group won NBC's The Sing-Off in 2011, they released eleven albums, which all charted in the top 5 of the Billboard 200 charts, have sold over 2 million records, and have amassed more than two billion views on their YouTube channel.

Ramsey Bethann Carpenter-Bearse is a convicted sex offender, and an American beauty pageant titleholder, and former teacher. She was named Miss Kentucky 2014 on July 12, 2014. She competed for the title of Miss America 2015, where she won the preliminary talent competition and placed in the Top 12 as a semi-finalist. Her platform issue was multiple sclerosis awareness.

Darrell Lee Waltrip is an American motorsports analyst, author, former national television broadcaster, and stock car driver. He raced from 1972 to 2000 in the former NASCAR Winston Cup Series, most notably driving the No. 17 Chevrolet for Hendrick Motorsports. Waltrip is a three-time Cup Series champion.

Michael Curtis Waltrip is an American former professional stock car racing driver, racing commentator, and published author. He is the younger brother of three-time NASCAR champion and racing commentator Darrell Waltrip. Waltrip is a two-time winner of the Daytona 500, having won the race in 2001 and 2003. He is also a pre-race analyst for the NASCAR Cup Series and color commentator for the Xfinity Series and the Gander RV & Outdoors Truck Series broadcasts for Fox Sports. He last raced in the 2017 Daytona 500, driving the No. 15 Toyota Camry for Premium Motorsports.

Reginald Volney Johnson was an American jazz double-bassist.

Terry Ballantine Bisson is an American science fiction and fantasy author. He is best known for his short stories, including "Bears Discover Fire", which won the Hugo Award and the Nebula Award, and "They're Made Out of Meat".

Stephen Frand Cohen was an American scholar of Russian studies. His academic work concentrated on modern Russian history since the Bolshevik Revolution and Russia's relationship with the United States.

Thomas McCreery Powers was an American actor in theatre, films, radio and television. A veteran of the Broadway stage, notably in plays by George Bernard Shaw, he created the role of Charles Marsden in Eugene O'Neill's Strange Interlude. He succeeded Orson Welles in the role of Brutus in the Mercury Theatre's debut production, Caesar. In films, he was a star of Vitagraph Pictures and later became best known for his role as the victim of scheming wife Barbara Stanwyck and crooked insurance salesman Fred MacMurray in the film noir classic, Double Indemnity (1944).