List of Famous people born in New York City, United States of America

John Saxon was an American actor who worked on more than 200 projects during a span of 60 years. He was known for his work in Westerns and horror films, often playing police officers and detectives.

John Anthony Frusciante is an American musician best known as the guitarist of the rock band Red Hot Chili Peppers. He has also released 12 solo albums and seven EPs.

Mia Sarapochiello, better known as Mia Sara, is an American actress. She is best known for her role as Sloane Peterson in the 1986 comedy film Ferris Bueller's Day Off, and other films such as Legend (1985), A Stranger Among Us (1992), Black Day Blue Night (1995), The Maddening (1995) and Timecop (1994).

Jeremiah O'Connell, known professionally as Jerry O'Connell, is an American actor, director and talk show host, known for his roles as Quinn Mallory in the television series Sliders, Andrew Clements in My Secret Identity, Vern Tessio in the film Stand by Me (1986), Joe in Joe's Apartment (1996), Frank Cushman in Jerry Maguire (1996), Derek in Scream 2 (1997), Charlie Carbone in Kangaroo Jack (2003), and Detective Woody Hoyt on the drama Crossing Jordan. He starred as Pete Kaczmarek in the single 2010–2011 season of The Defenders. He also had a starring role in the comedy horror film Piranha 3D (2010). Currently, he voices Commander Jack Ransom on the animated series Star Trek: Lower Decks.

Henry Louis Gehrig was an American professional baseball first baseman who played 17 seasons in Major League Baseball (MLB) for the New York Yankees (1923–1939). Gehrig was renowned for his prowess as a hitter and for his durability, which earned him his nickname "The Iron Horse". He was an All-Star seven consecutive times, a Triple Crown winner once, an American League (AL) Most Valuable Player twice, and a member of six World Series champion teams. He had a career .340 batting average, .632 slugging average, and a .447 on base average. He hit 493 home runs and had 1,995 runs batted in (RBI). He still has the highest ratio of runs scored plus runs batted in per 100 plate appearances (35.08) and per 100 games (156.7) among Hall of Fame players. In 1939, he was elected to the Baseball Hall of Fame and was the first MLB player to have his uniform number (4) retired by a team.

James Iovine is an American entrepreneur, record executive, and media proprietor best known as the co-founder of Interscope Records. In 2006, Iovine and rapper-producer Dr. Dre founded Beats Electronics, which produces audio products and operated a now-defunct music streaming service. The company was purchased by Apple Inc. for $3 billion in May 2014.

Ronald Joseph DeFeo Jr. is an American mass murderer who was tried and convicted for the 1974 killings of his father, mother, two brothers, and two sisters in Amityville, Long Island, New York. The case inspired the book and film versions of The Amityville Horror.

Mary Jane O'Meara Sanders is an American social worker, college administrator, activist and political strategist. Sanders was provost and interim president of Goddard College (1996–1997) and president of Burlington College (2004–2011). In June 2017, she founded the think tank The Sanders Institute. She has been married to U.S. Senator Bernie Sanders since 1988.

Melanie Adele Martinez is an American singer, songwriter, actress, director, photographer, screenwriter, and visual artist. Born in Astoria, Queens, and raised in Baldwin, New York, Martinez rose to prominence in 2012 after appearing on the American television vocal talent show The Voice. Following the show, she released her debut single "Dollhouse", followed by her debut EP of the same name (2014), through Atlantic Records.

Karen Civil is an American social media and digital media marketing strategist. She gained attention for creating and running Weezythanxyou.com, a website where the rapper Lil Wayne published letters to his fans while he was incarcerated at Rikers Island.