List of Famous people born in Canton of Schaffhausen, Switzerland

Roberto Di Matteo is an Italian former professional footballer and manager.

Christoph Blocher is a Swiss industrialist and politician who served as a Member of the Swiss Federal Council from 2004 to 2007. A member of the Swiss People's Party (SVP/UDC), he headed the Federal Department of Justice and Police. As an industrialist, he became wealthy as CEO and majority shareholder in the EMS-Chemie corporation, now run by his daughter, Magdalena Martullo-Blocher.

Mathias Gnädinger was a Swiss stage and film actor.

Beat Furrer is a Swiss-born Austrian composer and conductor. He has served as professor of composition at the University of Music and Performing Arts Graz since 1991. He won the Ernst von Siemens Music Prize in 2018.

Gilberto Agustoni was a Swiss prelate of the Roman Catholic Church. He worked in the Roman Curia from 1950 to 1998, ending his career as head of the Apostolic Signatura from 1992 to 1998. He became a Cardinal in 1994.

Irène Schweizer is a Swiss jazz and free improvising pianist. She was born in Schaffhausen, in 1941. She has performed and recorded numerous solo piano performances as well as performing as part of the Feminist Improvising Group, whose members include Lindsay Cooper, Maggie Nichols, Georgie Born and Sally Potter. She has also performed a series of duets with drummers Pierre Favre, Louis Moholo, Andrew Cyrille, Günter Sommer, Han Bennink, Hamid Drake, as well as in trio and quartet sessions with others, including John Tchicai, Evan Parker and Peter Kowald. With Yusef Lateef, Uli Trepte and Mani Neumeier she performed at the Montreux Jazz Festival in 1967. One of her most enduring collaborations is with the improvising musician Rüdiger Carl.

Leonie Küng is a Swiss tennis player. Küng has a career-high WTA singles ranking of No. 156, achieved on 17 February 2020. She also has a career-high WTA doubles ranking of No. 331, achieved on 19 August 2019. As a qualifier, Küng reached the singles final of the Junior Wimbledon Championships in 2018.

Niki Reiser is a Swiss film score composer and flautist. He is considered one of the most outstanding film composers of the German-speaking countries, winning the German Film Award five times. His debut was in 1986 the score for the film Du mich auch, directed by Dani Levy, for whom he has composed all further scores. He had his breakthrough with the music for the film Beyond Silence, directed by Caroline Link in 1996.

Hans Frauenfelder is a physicist and biophysicist notable for his discovery of perturbed angular correlation (PAC) in 1951. In the modern day, PAC spectroscopy is widely used in the study of condensed matter physics. Within biophysics, he is known for experiment and theory in understanding the dynamical behavior of protein tertiary structure.