List of Famous people born in Pennsylvania, United States of America

Howard Martin Temin was an American geneticist and virologist. He discovered reverse transcriptase in the 1970s at the University of Wisconsin–Madison, for which he shared the 1975 Nobel Prize in Physiology or Medicine with Renato Dulbecco and David Baltimore.

Dennis Patrick was an American character actor, primarily in television.

Jay Parini is an American writer and academic. He is known for novels, poetry, biography, screenplays and criticism. He has published novels about Leo Tolstoy, Walter Benjamin, Paul the Apostle, and Herman Melville.

Sidney George Fisher was a Philadelphia lawyer, farmer, plantation owner, political essayist and occasional poet.

Herbert Sargent was an American television writer, a producer for such comedy shows as The Tonight Show and Saturday Night Live, and a screenwriter. During his tenure at Saturday Night Live, he and Chevy Chase created Weekend Update, the longest-running sketch in the show's history, and one of the longest-running sketches on television.

Carl Kaysen was an American academic, policy advisor and international security specialist at the Massachusetts Institute of Technology (MIT) and co-chair of the Committee on International Security Studies at the American Academy of Arts and Sciences. He is the father of Girl, Interrupted author Susanna Kaysen. He was married for 50 years to Annette Neutra until her death in 1990. In 1994, he married Ruth Butler.

Mary Ellen Mark was an American photographer known for her photojournalism, documentary photography, portraiture, and advertising photography. She photographed people who were "away from mainstream society and toward its more interesting, often troubled fringes".

William Clarence Eckstine was an American jazz and pop singer and a bandleader during the swing era. He was noted for his rich, almost operatic bass-baritone voice. His recording of "I Apologize" was given the Grammy Hall of Fame Award in 1999. The New York Times described him as an "influential band leader" whose "suave bass-baritone" and "full-throated, sugary approach to popular songs inspired singers like Earl Coleman, Johnny Hartman, Joe Williams, Arthur Prysock and Lou Rawls."