List of Famous people who died at 49

Jean-François Cesarini was a French politician of La République En Marche! (LREM). He was a deputy to the French National Assembly for the department of Vaucluse from 19 June 2017 until his death in 2020.

Greg Clark was an American professional football player who was a tight end for the San Francisco 49ers in the National Football League (NFL). He was selected by the 49ers in the third round of the 1997 NFL Draft.

Gerard John Schaefer Jr. was an American murderer and suspected serial killer who was imprisoned in 1973 for murders he committed while he was a sheriff's deputy in Martin County, Florida. Schaefer was convicted of two murders, but was suspected of many others. He frequently appealed against his conviction, but privately boasted, both verbally and in writing, of killing more than thirty women and girls. In December 1995, Schaefer was stabbed to death in his prison cell.

Li Boguang was a Chinese legal scholar and human rights activist. In his capacity as the director of the Quimin Research Institute in Beijing, Li supported farmers in seeking compensation for confiscated farmland. He was arrested in 2004 following his involvement in the Tangshan protest, which led to international attention being paid to his plight by human rights groups.

Matthew Eric Wrinkles was a convicted multiple murderer. He served 14 years at Indiana State Prison in Michigan City, Indiana, and was executed there on December 12, 2009.

Steven Williams was an American professional wrestler, former collegiate football player, and amateur wrestler at the University of Oklahoma. Williams was known as "Dr. Death", a nickname he acquired in junior high school.

George Richard Moscone was an American attorney and Democratic politician. He was the 37th mayor of San Francisco, California from January 1976 until his assassination in November 1978. He was known as "the people's mayor", who opened up City Hall and its commissions to reflect the diversity of San Francisco. Moscone served in the California State Senate from 1967 until becoming Mayor. In the Senate, he served as Majority Leader.

Jeffrey John Hanneman was an American musician, best known as a founding member and lead guitarist of the American thrash metal band Slayer. Hanneman composed both music and lyrics for every Slayer album until his death in 2013 at age 49. He had his own signature guitar, the ESP Jeff Hanneman Signature model.

Abdul Ali Mazari was a Shiite militia and political leader of the Hezb-e Wahdat party during and following the Soviet–Afghan War. Mazari was an ethnic Hazara from Parwan province of Afghanistan who believed that the solution to the internal divisions in Afghanistan was in a federal system of governance, with each ethnic group having specific constitutional rights and able to govern their own land and people. He was allegedly tortured and murdered by the Taliban in 1995, and posthumously given the title ‘Martyr Of National Unity’ in 2016 by Ashraf Ghani government. He supported equal representation of all ethnic groups of Afghanistan, especially Hazaras, who are still being persecuted in Afghanistan.

Ken Morioka was a Japanese musician, keyboardist, composer, and music producer. He died of heart failure at the age of 49.