List of Famous people born in Valparaíso Region, Chile

Marcela Cubillos Sigall is a Chilean politician and lawyer, militant from Unión Demócrata Independiente (UDI). She was Minister of State in Education and Environment portfolios from 2018 to 2020, during the second government of Sebastián Piñera (2018–2022).

Andrés Celis Montt is a Chilean lawyer and politician.

Macarena Carolina Ripamonti Serrano is a Chilean politician. She is the mayor of Viña del Mar.

Cristián Alejandro Contreras Radovic, popularly known as Dr. File, is a Chilean journalist, writer, and philosopher known for spreading conspiracy theories and pseudosciences in the Chilean media. He is the current leader of the political party United Center, and was also a candidate for becoming a Senator of the Metropolitan Region of Chile.

Elisa Breton, was a French artist and writer, and the third wife of the French writer and surrealist André Breton.

Sergio Otoniel Contreras Navia was a Chilean Catholic bishop.

Gunther Alberto Uhlmann Arancibia is a mathematician whose research focuses on inverse problems and imaging, microlocal analysis, partial differential equations and invisibility.