List of Famous people born in South Carolina, United States of America

Jesse Louis Jackson is an American political activist, Baptist minister, and politician. He was a candidate for the Democratic presidential nomination in 1984 and 1988 and served as a shadow U.S. Senator for the District of Columbia from 1991 to 1997.

Darius Carlos Rucker is an American singer and songwriter. He first gained fame as the lead vocalist and rhythm guitarist of rock band Hootie & the Blowfish, which he founded in 1986 at the University of South Carolina along with Mark Bryan, Jim "Soni" Sonefeld, and Dean Felber. The band released five studio albums with him as a member and charted six top 40 hits on the Billboard Hot 100. Rucker co-wrote most of the songs with the other members.

Ben Domenech is an American writer, blogger, editor and television commentator. He is the co-founder and the publisher of The Federalist, host of The Federalist Radio Hour, and writes The Transom, a daily subscription newsletter for political insiders. He also co-founded the RedState group blog.

Shelby Rogers is an American tennis player from Mount Pleasant, South Carolina. She won the Girls National Championship at 17. Her best results as a professional came at the 2016 French Open and the 2020 US Open where she reached the quarterfinals. She has a career-high WTA singles ranking of No. 48, while her highest doubles ranking is No. 101. She has won 6 singles titles and 2 doubles titles on the ITF Circuit.

Brett Michael Gardner is an American professional baseball outfielder who is a free agent. Gardner made his Major League Baseball (MLB) debut with the New York Yankees in 2008 and was a part of the Yankees' 2009 World Series championship team over the Philadelphia Phillies. He was named an All-Star in 2015 and won a Gold Glove Award in 2016.

Nancy O'Dell is an American television host and entertainment journalist. She served as co-anchor of the syndicated entertainment news show Entertainment Tonight from January 3, 2011, to August 2, 2019.

Jermaine O'Neal is an American former professional basketball player. The center–power forward had a successful high school career and declared his eligibility for the 1996 NBA draft straight out of high school. O'Neal, at just 17 years of age, was selected by the Portland Trail Blazers with the 17th overall pick, and played his first professional game at 18. At the time, he was the youngest player to ever play an NBA game.

Macey Estrella-Kadlec is an American professional wrestler currently signed to WWE, where she performs on the Raw brand under the ring name Lacey Evans.

Ty'Son Williams is an American football running back for the Baltimore Ravens of the National Football League (NFL). He went undrafted in the 2020 NFL Draft. He played college football at South Carolina and BYU.

Melvin Horace Purvis II was an American law enforcement official and Federal Bureau of Investigation (FBI) agent. Given the nickname "Little Mel" because of his short, 5 ft 4 in (163 cm) frame, Purvis became noted for leading the manhunts that captured or killed bank robbers such as Baby Face Nelson, John Dillinger, and Pretty Boy Floyd, but his high public profile was resented by local law enforcement. Purvis asserted he had killed Floyd single-handed, others variously claimed that Floyd had been already wounded, or even that Purvis had ordered Floyd summarily shot dead for refusing to provide information.