List of Famous people born in South Carolina, United States of America

Mike Randal Colter is an American actor best known for his role as Luke Cage in Marvel's Luke Cage (2016–2018), The Defenders (2017), and Jessica Jones, all set in the Marvel Cinematic Universe. He has also appeared as Lemond Bishop in the television series The Good Wife (2010–2015) and The Good Fight (2017–present), Malcolm Ward in Ringer (2011–2012), Jameson Locke in the Halo franchise (2014–2015) and Agent J's father in Men in Black 3.

Madelyn Renee Cline is an American actress. She is known for her starring role as Sarah Cameron on the Netflix teen drama series Outer Banks.

William Rankin Patton is an American actor and audiobook narrator. He starred as Colonel Dan Weaver in the TNT science fiction series Falling Skies. He also appeared in the films Remember the Titans, Armageddon, Gone in 60 Seconds and The Punisher. He appeared opposite Kevin Costner in two films: No Way Out (1987) and The Postman (1997). He won two Obie Awards for best actor in Sam Shepard's play Fool for Love and the Public Theater production of What Did He See?.

Joshua Ricardo Norman is an American football cornerback for the Buffalo Bills of the National Football League (NFL). He played college football at Coastal Carolina and was drafted by the Carolina Panthers in the fifth round of the 2012 NFL Draft, later playing for the Washington Redskins. Norman was considered to be among the best cornerbacks in the NFL during the mid-2010s. He also participated in the celebrity dancing competition show Dancing with the Stars, finishing as the runner-up of its 26th season in 2018.

Ruston Samuel Kelly is an American singer-songwriter. After landing a publishing deal with BMG Nashville in 2013, he got his first cut with Tim McGraw's song "Nashville Without You", which appeared on McGraw's album Two Lanes of Freedom. Following a record deal with Razor & Tie's Washington Square, he released his debut EP Halloween produced by Mike Mogis in 2017.

Jaimie Lauren Alexander is an American actress. She is known for portraying Jessi on the TV series Kyle XY and Lady Sif in the Marvel Cinematic Universe. From 2015 until 2020, she starred in the NBC series Blindspot.

Timothy Eugene Scott is an American politician and businessman serving as the junior United States Senator for South Carolina since 2013. A Republican, Scott was appointed to the U.S. Senate by Governor Nikki Haley in 2013. He retained his seat after winning a special election in 2014 and was elected to a full term in 2016.

Matthew Scribner Wells is an American football coach and former quarterback who is currently the head coach at Texas Tech University. Wells previously served as the offensive coordinator and then head coach at Utah State University, where he was named Mountain West conference coach of the year in 2013 and again in 2018. He was named head coach of Texas Tech on November 29, 2018.

James Khristian Middleton is an American professional basketball player for the Milwaukee Bucks of the National Basketball Association (NBA). He attended high school at the Porter-Gaud School in Charleston, South Carolina. As a junior and senior, he was named South Carolina Player of the Year, and was a McDonald's All-American nominee. After being recruited by Scott Spinelli, he went on to play college basketball for Texas A&M University, where he started the majority of the games in his freshman year. In his sophomore season, he earned second-team All-Big 12 honors after leading the Aggies in scoring with 14.3 points per game. Middleton was selected by the Detroit Pistons with the 39th overall pick of the 2012 NBA draft. He received his first All-Star selection in 2019.

Ellsworth Raymond "Bumpy" Johnson was an American drug trafficker in the Harlem neighborhood of New York City.