List of Famous people born in South Carolina, United States of America

Stephon Stiles Gilmore is an American football cornerback for the New England Patriots of the National Football League (NFL). Gilmore played college football for South Carolina and was drafted by the Buffalo Bills tenth overall in the 2012 NFL Draft. After five seasons as a starting cornerback for the Bills and a Pro Bowl invite in 2016, Gilmore signed a 5-year, $65 million contract with New England in 2017. He has since emerged as one of the league's top defensive players, garnering three more Pro Bowl invites and first-team All-Pro recognitions in 2018 and 2019, as well as being named AP NFL Defensive Player of the Year in 2019.

Aziz Ismail Ansari is an American actor, writer, producer, director, and comedian. He is known for his role as Tom Haverford on the NBC series Parks and Recreation (2009–2015) and as creator and star of the Netflix series Master of None (2015–) for which he won several acting and writing awards, including two Emmys and a Golden Globe, which was the first award received by an Asian American actor for acting on television.

Temetrius Jamel "Ja" Morant is an American professional basketball player for the Memphis Grizzlies of the National Basketball Association (NBA). He played college basketball for the Murray State Racers, where he was a consensus first-team All-American as a sophomore in 2019. He was selected by the Grizzlies with the second overall pick in the 2019 NBA draft and named the NBA Rookie of the Year in 2020.

Vanna Marie White is an American television personality and film actress known as the hostess of Wheel of Fortune since 1982.

Dylann Storm Roof is an American white supremacist, neo-Nazi and mass murderer convicted for perpetrating the Charleston church shooting on June 17, 2015, in the U.S. state of South Carolina. During a Bible study at Emanuel African Methodist Episcopal Church, Roof killed nine people, all African Americans, including senior pastor and state senator Clementa C. Pinckney, and injured one other person. After several people identified Roof as the main suspect, he became the center of a manhunt that ended the morning after the shooting with his arrest in Shelby, North Carolina. He later confessed that he committed the shooting in hopes of igniting a race war. Roof's actions in Charleston have been widely described as domestic terrorism.

Brett Mason Rudolph III is an American football quarterback for the Pittsburgh Steelers of the National Football League (NFL). He played college football at Oklahoma State, where he was a three-year starter and won the Johnny Unitas Golden Arm Award during his last year. He was selected by the Steelers in the third round of the 2018 NFL Draft.

Dewey LaMarr Hoyt Jr. was an American professional baseball right-handed pitcher. He played in Major League Baseball for the Chicago White Sox and San Diego Padres from 1979 to 1986. He won the 1983 American League Cy Young Award and was an All-Star in 1985.

Cordarrelle Patterson, nicknamed "Flash", is an American football wide receiver and return specialist for the Chicago Bears of the National Football League (NFL). He was drafted by the Minnesota Vikings in the first round of the 2013 NFL Draft. He played college football at Tennessee.

Jay Wayne Jenkins, known professionally as Jeezy, is an American rapper, singer, songwriter, and actor. Signed to Def Jam Recordings since 2004, his major label debut Let's Get It: Thug Motivation 101 was released the following year and debuted at #2 on the Billboard 200, selling 172,000 copies in its first week and was later certified platinum by the Recording Industry Association of America (RIAA). Jeezy is credited, along with fellow Atlanta-based rappers T.I. and Gucci Mane, for helping to pioneer and popularize trap music with a mainstream audience.

Adriel Jeremiah Green is an American football wide receiver for the Cincinnati Bengals of the National Football League (NFL). He played college football at the University of Georgia for the Georgia Bulldogs, and was drafted by the Bengals fourth overall in the 2011 NFL Draft.