List of Famous people born in Santiago Metropolitan Region, Chile

Manuela Abril Martelli Salamovich is a Chilean film and television actress best known for her roles in the films B-Happy and Machuca. She starred with the famous dutch actor Rutger Hauer in the chilean-italian films Il Futuro, based on Roberto Bolaño's novel A Little Lumpen Novelita.

Francisca Crovetto Chadid is a Chilean sport shooter. She won a silver medal in the women's skeet at the 2011 Pan American Games in Guadalajara, Mexico, accumulating a score of 89 targets, and a bronze medal in the same event at the 2015 Pan American Games in Toronto.

Nicolás Iván Orellana Acuña is a Chilean footballer who currently plays for Audax Italiano as a striker.

Lorenzo Enrique Reyes Vicencio is a Chilean professional footballer who plays as a central midfielder for Liga MX club Mazatlán and the Chile national team.

Diamela Eltit is a Chilean writer and university professor. She is a recipient of the National Prize for Literature.

Héctor Rosendo Robles Fuentes is a Chilean coach and former footballer.

Saint Teresa of Jesus of Los Andes - born as Juana Fernández Solar - was a Chilean professed religious from the Discalced Carmelites. Fernández Solar was a pious child but had an often unpredictable temperament for she could be prone to anger and being vain but could also demonstrate her charitable and loving nature; she seemed transformed when she decided to become a nun and her character seemed to change for her sole ambition was to dedicate herself to the service of God. But her time in the convent was cut short due to her contracting an aggressive disease that killed her - she knew she would die but was consoled knowing she would be able to make her profession before she died.

Juan Carlos Sáez is a Chilean tennis player. Sáez has a career high ATP singles ranking of 230 achieved on 28 September 2015. Sáez has won 8 ITF singles events and 20 ITF doubles events on the futures circuit. Sáez made his ATP main draw doubles debut at the 2014 Royal Guard Open, partnering Gonzalo Lama losing to Daniele Bracciali and Potito Starace in the first round, 0–6, 6–3, [6–10]. In August 2019 Sáez was banned for eight years for match-fixing.

Ana María Gazmuri Vieira is a Chilean actress and activist.

Rodrigo Andrés Ureña Reyes is a Chilean footballer who plays for América de Cali as a midfielder.