List of Famous people born in Santiago Metropolitan Region, Chile

Catalina Isabel Palacios Galindo, nickname Cata Palacios is a Chilean actress, singer and television presenter. She is known mostly for being in the cast of the youth program Mekano, for her role in the 2005 television series Magi-K, and for being the host of the youth program Yingo. She has participated in the 2008 Chilean telethon, Chile ayuda a Chile, and Dancing with the Stars.

Osvaldo Andrade Lara is a Chilean Socialist politician. After studying law at the Pontifical Catholic University of Chile, Andrade joined the Socialist Party in 1968. He served as director of the Young Socialists. Following the Chilean coup of 1973, he was detained at the Estadio Nacional and at Villa Grimaldi. He was Minister of Labor and Social Security in the government of Chilean President Michelle Bachelet from 2006 to 2008. On 22 March 2016 he became President of the Chamber of Deputies. He succeeded Marco Antonio Núñez. He was succeeded as president on 22 March 2017 by Fidel Espinoza.

Darío Esteban Melo Pulgar is a Chilean footballer who plays for Colo-Colo.

Andrés Velasco Brañes is an economist and professor. He served as the finance minister of Chile from March 2006 to March 2010, the whole of the first presidential period of Michelle Bachelet. He is currently the Dean of the School of Public Policy at the London School of Economics.

José De Gregorio Rebeco is a Chilean economist, academic, researcher, consultant and politician. He has been the Governor of the Central Bank of Chile, Minister of the Economy, Mining and Energy during the administration of Ricardo Lagos and is currently the Dean of the School of Economics and Business of the Universidad de Chile. He is also a nonresident Senior Fellow at the Peterson Institute for International Economics.

Adriana Blanca Cristina Muñoz d'Albora is a Chilean sociologist and politician who serves as a member of the Senate of Chile, representing the 4th constituency of the Coquimbo Region. She previously served as president of the Senate of Chile.

Pablo Valenzuela is a Chilean biochemist dedicated to biotechnology development. He is known for his genetic studies of hepatitis viruses; participated as R&D Director in the discovery of hepatitis C virus and the invention of the world's first recombinant vaccine. He is one of the cofounders of the biotechnology company Chiron Corporation and of Fundacion Ciencia para la Vida, a private non profit institution where he is currently working.

María Alejandra Herrera Andreucci is a Chilean actress known mainly for starring in the telenovelas Amor a domicilio, Adrenalina y Marparaíso on Canal 13 and in La Nany on Mega.

German Casas is a Chilean singer.

Alain Johannes Mociulski is a Chilean-American multi-instrumentalist and vocalist, whose primary instruments are guitar and bass. He is a founding member of several bands, including the alternative rock group Eleven, and has been involved with acts such as hard rock band Queens of the Stone Age, Them Crooked Vultures, PJ Harvey, Chris Cornell, Arctic Monkeys, Mark Lanegan and The Desert Sessions, both as a musician and as a producer.