List of Famous people born in Santiago Metropolitan Region, Chile

Manuel Jesús Plaza Reyes was a long-distance runner from Chile. He competed in the marathon at the 1924 and 1928 Olympics and won a silver medal in 1928, becoming the first Olympic medalist from Chile. He placed sixth in 1924, and served as the flag bearer for Chile at both Olympics.

Juan Miguel Fuente-Alba Poblete is a retired senior Chilean soldier. He held the position of Commander in Chief of the Chilean Army between March 10, 2010 and March 9, 2014. He is currently serving a sentence in prison for tax fraud and embezzlement during his time as a general in the "Milicogate" case.

Eros Roque Pérez Salas is a Chilean former footballer and journalist.

Francisco José Cox Huneeus was a native of Chile and a former archbishop of the Catholic Church. He was a member of the Schoenstatt Movement. He was Bishop of Chillán from 1975 to 1981 and Coadjutor Archbishop of La Serena from 1985 to 1990 and Archbishop there from 1990 to 1997, when he resigned following accusations that he had sexually abused young boys. He was laïcized in 2018.

Ariel Mateluna is a Chilean actor. He appeared in more than twenty films since 2004.

Mónica González Mujica is a Chilean writer and journalist. She won the Maria Moors Cabot Prize in 2002, the Dan David Prize in 2006 and UNESCO/Guillermo Cano World Press Freedom Prize 2010. From 2005-2006 she was editor of es:Diario Siete, a daily paper in Santiago de Chile which ran for a year.

Paulina García Alfonso, better known as Pali García, is a Chilean actress, theatre director and playwright.

Elisa Zulueta is a Chilean television, theatre and film actress who studied at the Pontificia Universidad Católica de Chile. Formerly, she worked for TVN where she made little works in telenovelas and series. In 2008 she gained fame with the role of Julia Amigo in the telenovela Lola of Canal 13. In 2009, Elisa Zulueta and Emilio Edwards were the main roles for the Chilean film Tanto Tiempo, directed by Claudio Polgati, this film won two prizes in the eight version of the Festival Internacional de Cine Chico de Canarias.

María Esperanza Silva Soura is a Chilean actress, theater director and union leader, with a career in theater, film and television. She is the daughter of the prominent Chilean announcer and actor Sergio Silva Acuña.

José Miguel Carlos Piñera Echenique, known in Chile by his nickname "Negro" Piñera is a Chilean celebrity, night club owner and amateur musician. He is the brother of President of Chile Sebastián Piñera and of economist José Piñera. Piñera was married to Argentinean model Belén Hidalgo. Negro Piñera is of Asturian and Basque descent.