List of Famous people born in Santiago Metropolitan Region, Chile

Camila Moreno is a Chilean rock and folk singer-songwriter.

María Francisca "Kika" Silva Sánchez is a Chilean model, actress and television personality.

Jorge Antonio Zabaleta Briceño is a prominent Chilean actor. He is the son of the musician Antonio Zabaleta and the nephew of Miguel Zabaleta, both members of the duo Red Juniors.

Gabriel Osorio Vargas is a Chilean film director. He is best known for directing, animating and writing the short animated film Bear Story (2015), which won the Oscar in the category of Best Animated Short Film at the 88th Academy Awards; the first Chilean film to do so. He shared the win with producer Pato Escala Pierart. The film also entered various film festivals worldwide, receiving numerous awards and nominations. He has his own animation studio named Punkrobot. Since 2008, he has been directing various animated television series for children and television adverts.

Hernán Larraín Fernández is a conservative Chilean lawyer, university lecturer, and politician; he is the current Chilean Minister of Justice and Human rights appointed by president Sebastián Piñera. Larraín's former public service positions include a Senate seat representing the 11th district, the Maule Region (1994-2010), the Presidency of the Senate (2004-2005) and the presidency of the Independent Democratic Union from 2006 to 2008 and 2015–2017. The UDI is a conservative political party with strong links to the Opus Dei, that opposes abortion and has historically supported Augusto Pinochet dictatorship. His appointment as Minister of Justice and Human rights has been controversial despite his attempt to distance himself from the UDI's ideology regarding human rights to achieve a more conciliatory tone as a minister.

Carlos Larraín was the President of National Renewal.

Kristel Arianne Köbrich Schimpl is an Olympic long-distance freestyle swimmer from Chile. She was the country's flagbearer at the 2004 Olympics, and also swam at the 2008 Games and at the 2012 Games.

Claudia Andrea Burr Huerta is a Chilean film and television actress.

Pablo Alfonso Schwarz Rabinovich is a Chilean actor, noted for his extensive television, theater and film career.

José Andrés Rafael Zaldívar Larraín, popularly known as El Chico Zaldívar, is a prominent Chilean Christian Democrat politician. Andrés Zaldívar is of Basque descent.