List of Famous people born in Santiago Metropolitan Region, Chile

Milovan Petar Mirošević Albornoz is a retired Chilean footballer. He spent the majority of his playing career as an attacking midfielder for Universidad Católica. He is also commonly known as Milo Mirosevic.

Sebastián Rozental Igualt is a retired Chilean professional footballer.

Ariel Levy Dor is a Chilean actor, professional wrestler and singer. He is best known for playing Javier Fernández, the main character in the Nicolás López comic film trilogy Qué pena tu..., Pablo 'Carpa' Parra in Mala Conducta, Adamo Curilén in La Sexóloga, Ariel in Aftershock and Alejandro in The Green Inferno.

Karol Jesús Lucero Venegas, also known by his old stage name, Karol Dance, is a Chilean television presenter, radio host and businessman. He has also dabbled as a singer and actor.

Frank Lobos is a Chilean former football playing as a midfielder. He was punished by the Disciplinary Court of the ANFP with 10 years of total disability in everything that relates to professional football after being found guilty of bribery.

Gonzalo Andrés Lama Feliu is a Chilean tennis player. He has won two Challengers, along with ten futures, eight in singles and two in doubles. He has defeated top 100 players such as Robin Haase, Alejandro González, Víctor Estrella, Pere Riba, Boris Pašanski, Blaz Kavcic and Potito Starace. His best ranking was 160° in June 2016.

Katherine Estrella Salosny Reyes is a Chilean actress and television presenter.

Juan Carlos Jobet Eluchans is a Chilean politician and former member of Renovación Nacional. He is the Minister of Mining of Chile since 2020.

Kudai are a Latin Grammy Award-nominated Chilean pop group that was founded in Santiago, Chile. Its original members were Tomás Manzi, Pablo Holman, Nicole Natalino and Bárbara Sepúlveda Labra. In 2006 Nicole Natalino left the group citing personal reasons, and was replaced by Ecuadorian Gabriela Villalba for three years. They released five albums in Latin America: Vuelo in 2004, Sobrevive in 2006, Nadha in 2008, Laberinto in 2019 and Revuelo in 2021.

José Jaime Parada Hoyl is a Chilean gay rights activist and politician who became the first openly gay person elected to public office in Chile. He serves as the spokesperson for Movimiento de Integración y Liberación Homosexual, the leading Chilean gay rights organization. He was elected councilman for his home commune of Providencia for the 2012–2016 term.