List of Famous people born in Region of Murcia, Spain

Enrique Cedeño Martinez, better known by his in-game name xPeke, is a retired professional League of Legends player. He was the founder and owner of Origen, which competed in the LEC, the top level of professional League of Legends in Europe. Martinez is best known for his spell with Fnatic, with whom he has won three League of Legends Championship Series Europe titles and the Season 1 World Championship.

Nicolás Almagro Sánchez is a retired Spanish professional tennis player. He reached the quarterfinals of the French Open in 2008, 2010 and 2012, as well as the quarterfinals of the Australian Open in 2013. Almagro has won 13 singles titles and he achieved his career-high singles ranking of World No. 9 in May 2011.

David Antón Guijarro is a Spanish chess player. He was awarded the title of Grandmaster by FIDE in 2013, at the age of 18. He has competed at two chess olympiads.

Gonzalo Villar del Fraile is a Spanish professional footballer who plays for Serie A club Roma as a central midfielder.

Eva Llorach is a Spanish actress. Her breakout performance was her role in the 2018 drama film Quién te cantará, which earned her the Goya Award for Best New Actress in 2019.

Laura Gil is a Spanish basketball player for CB Avenida and the Spain women's national basketball team. At club level, she has been on teams that won the 2011 EuroLeague and three Spanish Leagues competitions. As a member of the Spain national teams, she has been a medallist in all the tournaments she has played in from 2007 to 2019: nine medals at youth level and seven medals at senior level. The last medal won was gold at the EuroBasket Women 2019.

Miguel Ángel López Nicolás is a Spanish racewalker. He won the gold medal in the 20 km race walk at the 2015 World Championships and the silver in 2013. He competed in the 20 km walk at the 2012 Summer Olympics, where he placed fifth, and the 50 km walk at the 2016 Olympics.

Isabel Franco may refer to:

• Isabel Franco Sánchez, Spanish journalist and politician
• Isabel Franco Carmona, Spanish Podemos politician

Luis León Sánchez Gil is a Spanish road bicycle racer, who currently rides for UCI WorldTeam Astana–Premier Tech. Sánchez's major achievements include winning the overall classifications of the 2009 Paris–Nice and the 2005 Tour Down Under, as well as the one-day race Clásica de San Sebastián in 2010 and 2012. He also has 4 Tour de France stage victories and is a four-time winner of the Spanish National Time Trial Championships. He is a time trial specialist and has improved his climbing skills over the course of his career.

José Carlos Martínez is a Spanish dancer and choreographer, Danseur Étoile of the Paris Opera Ballet, and since December 2010, artistic director of the Spanish National Dance Company.