List of Famous people born in O'Higgins Region, Chile

Eduardo Artés Brichetti is a Chilean educator and political figure. He is the leader of the Chilean Communist Party and Patriotic Union, which nominated him as a candidate for the 2017 presidential election.

Anthony "Tony" DeAngelo is an American professional ice hockey defenseman for the New York Rangers of the National Hockey League (NHL). DeAngelo was selected by the Tampa Bay Lightning in the first round, 19th overall, of the 2014 NHL Entry Draft.

Humberto Gatica is a Chilean-born American recording engineer, mixing engineer and record producer, best known for his work with Celine Dion, Chicago, Michael Jackson, Barbra Streisand, Andrea Bocelli, Josh Groban and Michael Bublé. Gatica's international collaborations include producing artists singing in over six languages.

Mario Adolfo del Carmen Fernández Baeza is a Chilean lawyer, professor and politician, member of the Christian Democratic Party. He served as the Minister of the Interior and Public Security in Michelle Bachelet's second term.

Bryan Martín Rabello Mella is a Chilean professional footballer who plays as an attacking midfielder.

Carlos Remigio Cardoen Cornejo is a Chilean metallurgical engineer, weapons scientist and agricultural businessman.

Ricardo Roberto Toro Lavín, also known as Buddy Richard is a Chilean singer-songwriter known for his ballads.

Víctor Hugo Castañeda is a Chilean football former footballer and current manager.

Gabriel Rafael Mendoza Ibarra, commonly known as Coca Mendoza for his similarity with the television actress Coca Guazzini, is a former Chilean footballer that played in the position of right back and central midfielder.

Richard R. Burt is an American businessman and diplomat who served as United States Ambassador to Germany and was a chief negotiator of the Strategic Arms Reduction Treaty. Prior to his diplomatic career, Burt worked as director of a non-governmental organization and from 1977 to 1980 was a national security correspondent for The New York Times.