List of Famous people born in Missouri, United States of America

Phyllis Smith is an American actress and casting associate. She is best known for playing Phyllis Vance in the television series The Office and her critically acclaimed voice role as Sadness in the film Inside Out. She also had a regular role on the Netflix series The OA.

Craig Kilborn is an American comedian, sports and political commentator, actor, and television host. Kilborn began a career in sports broadcasting in the late 1980s, leading to an anchoring position at ESPN's SportsCenter from 1993 to 1996. He was later the first host of The Daily Show, which he hosted from 1996–1998, and succeeded Tom Snyder on CBS' The Late Late Show from 1999–2004. On June 28, 2010, he launched The Kilborn File after a six-year absence from television, which aired on some Fox stations for a six-week trial run. In comedy, he is known for his deadpan delivery.

Julia Boggs Grant was the First Lady of the United States and wife of Ulysses S. Grant. Her time as First Lady marked a turning point in her life, when she became a national figure. Her memoirs, The Personal Memoirs of Julia Dent Grant were published in 1975.

Robert Rayford, sometimes identified as Robert R. due to his age, was a teenager from Missouri who has been suggested to represent the earliest confirmed case of HIV/AIDS in North America based on evidence which was published in 1988 in which the authors claimed that medical evidence indicated that he was "infected with a virus closely related or identical to human immunodeficiency virus type 1." Rayford died of pneumonia, but his other symptoms baffled the doctors who treated him. A study published in 1988 reported the detection of antibodies against HIV. Results of testing for HIV genetic material were reported once at a scientific conference in Australia in 1999; however, the data has never been published in a peer-reviewed medical or scientific journal.

Landry Michael Shamet is an American professional basketball player for the Brooklyn Nets of the National Basketball Association (NBA). He played college basketball for the Wichita State Shockers.

Ryan James Howard, nicknamed "The Big Piece", is an American former professional baseball first baseman. Howard spent his entire Major League Baseball (MLB) career playing for the Philadelphia Phillies, from 2004 to 2016. He is known for being the fastest player in baseball history to reach 100 home runs, and 200 home runs. Howard holds numerous Phillies franchise records.

Julia Lorraine Hill is an American environmental activist and tax redirection advocate. She is best known for having lived in a 180-foot (55 m)-tall, roughly 1500-year-old California redwood tree for 738 days between December 10, 1997 and December 18, 1999. Hill lived in the tree, affectionately known as Luna, to prevent Pacific Lumber Company loggers from cutting it down. She is the author of the 2000 book The Legacy of Luna and co-author of One Makes the Difference.

John Cone is an American professional wrestling referee who works for the WWE under the Raw brand.

William Seward Burroughs II was an American writer and visual artist. Burroughs was a primary figure of the Beat Generation and a major postmodern author whose influence affected popular culture as well as literature. Burroughs wrote eighteen novels and novellas, six collections of short stories and four collections of essays. Five books have been published of his interviews and correspondences. He also collaborated on projects and recordings with numerous performers and musicians and made many appearances in films. He was also briefly known by the pen name William Lee. Burroughs created and exhibited thousands of paintings and other visual artworks, including his celebrated 'Gunshot Paintings'.

Thomas Stearns Eliot was a poet, essayist, publisher, playwright, literary critic and editor. Considered one of the 20th century's major poets, he is a central figure in English-language Modernist poetry.