List of Famous people born in Lazio, Italy

Simonetta Di Pippo is an Italian astrophysicist and the current Director of the United Nations Office for Outer Space Affairs (UNOOSA). She holds a Master’s Degree in Astrophysics and Space Physics from University "La Sapienza", and an Honoris Causa Degree in Environmental Studies, and an Honoris Causa Degree of Doctor in International Affairs. In 2008, the International Astronomical Union (IAU) named asteroid 21887 "dipippo" in honour of her contribution to space activities and in 2006, she was knighted by the President of the Italian Republic Carlo Azeglio Ciampi.

Gianluca Frabotta is an Italian professional footballer who plays as a left-back for Serie A club Juventus.

Aitana Sánchez-Gijón de Angelis is a Spanish film actress.

Clara Petacci, known as Claretta Petacci, was a mistress of the Italian dictator Benito Mussolini. She was killed during Mussolini's execution by Italian partisans, throwing herself on him in a vain attempt to protect him from the bullets.

Luigi "Gigi" Proietti was an Italian actor, voice actor, comedian, director, musician, singer and television presenter.

Daniel Sallis Huston is an American actor, writer, and director. Huston got his start directing Mr. North, starring Anthony Edwards, Robert Mitchum, and Huston's half-sister, Anjelica Huston. Later, Huston gave his breakthrough acting performance in the independent film Ivans Xtc and was nominated for Best Male Performance at the Independent Spirit Awards in 2003.

Felix Anthony Silla, also credited as Felix Cilla, is a retired Italian-born American film and television actor and stuntman, known for his recurring role as the costumed character of "Cousin Itt" on television's The Addams Family, with the voice usually provided by Anthony Magro (1923–2004). Silla also appeared in many other classic character roles.

Enrico Fermi was an Italian physicist and the creator of the world's first nuclear reactor, the Chicago Pile-1. He has been called the "architect of the nuclear age" and the "architect of the atomic bomb". He was one of very few physicists to excel in both theoretical physics and experimental physics. Fermi was awarded the 1938 Nobel Prize in Physics for his work on induced radioactivity by neutron bombardment and for the discovery of transuranium elements. With his colleagues, Fermi filed several patents related to the use of nuclear power, all of which were taken over by the US government. He made significant contributions to the development of statistical mechanics, quantum theory, and nuclear and particle physics.

Sergio Castellitto is an Italian actor, film director, and screenwriter.

Alessandro Gassmann is an Italian actor.