List of Famous people born in Charlottesville, United States of America

Robert Hepler Lowe is an American actor, producer, and director. He made his acting debut at the age of 15 with ABC's short-lived sitcom A New Kind of Family (1979–1980). Following numerous television roles in the early 1980s, he came to prominence as a teen idol and member of the Brat Pack with roles in films like The Outsiders (1983), Class (1983), The Hotel New Hampshire (1984), Oxford Blues (1984), St. Elmo's Fire (1985), About Last Night... (1986), and Square Dance (1987). The success of these films established him as a Hollywood star.

Camila Carraro Mendes is an American actress and singer. She is known for portraying Veronica Lodge on The CW teen drama television series Riverdale.

Richard Mauze Burr is an American politician serving as the senior United States Senator from North Carolina, serving since 2005. A member of the Republican Party, Burr was previously a member of the United States House of Representatives.

Jason Eric Kessler is an American neo-Nazi, white supremacist and anti-semitic conspiracy theorist. Kessler organized the Unite the Right rally held in Charlottesville, Virginia on August 11–12, 2017 and the Unite the Right 2 rally held on August 12, 2018.

Alexander Mattheus Michel is an American businessman, producer, and television personality. He is best known for being the first star of The Bachelor during its premiere season on ABC in 2002.

Sarah White Drew is an American actress and director. She is known for playing Hannah Rogers in The WB family drama series Everwood (2004–2006) and Dr. April Kepner in the ABC medical drama series Grey's Anatomy (2009–2018).

Meriwether Lewis was an American explorer, soldier, politician, and public administrator, best known for his role as the leader of the Lewis and Clark Expedition, also known as the Corps of Discovery, with William Clark. Their mission was to explore the territory of the Louisiana Purchase, establish trade with, and sovereignty over the natives near the Missouri River, and claim the Pacific Northwest and Oregon Country for the United States before European nations. They also collected scientific data, and information on indigenous nations. President Thomas Jefferson appointed him Governor of Upper Louisiana in 1806. He died of gunshot wounds in what was either a murder or suicide, in 1809. The Louisiana Purchase was not made official until July 1803, Jefferson still requested Congress to fund the expedition in January of the same year.

Carrie Elizabeth Buck was the plaintiff in the United States Supreme Court case Buck v. Bell, after having been ordered to undergo compulsory sterilization for purportedly being "feeble-minded." The surgery, carried out while Buck was an inmate of the Virginia State Colony for Epileptics and Feebleminded, took place under the authority of the Eugenical Sterilization Act of 1924, part of the Commonwealth of Virginia's eugenics program.

Boyd Calvin Tinsley is an American violinist and mandolinist who is best known for having been a member of the Dave Matthews Band.

Nathan Daniel Larson is an American accountant and perennial candidate. He served 14 months in prison for the felony of threatening the President of the United States. He has advocated for curtailing women's rights and decriminalizing child sexual abuse and incest. He is a white supremacist. In 2020, Larson was arrested at Denver International Airport for allegedly kidnapping a 12-year-old girl. During a search of his home, detectives found evidence suggesting he operated a website encouraging pedophilia and child rape.