List of Famous people born in Centre-Val de Loire, France

Louis II de la Trémoille, also known as La Trimouille, was a French general. He served under three kings: Charles VIII, Louis XII and Francis I. He was killed in combat at the Battle of Pavia.

Thibault Métezeau was a French architect. He was the son of Clément Métezeau, master mason and father of architects Louis and Clément II Métezeau. He was the brother of Jean Métezeau, also an architect.

Louis Jacques Balsan was a French aviator and industrialist, born at Châteauroux (Indre) in 1868, who was the second husband of society beauty Consuelo Vanderbilt, Duchess of Marlborough. He married her immediately after her divorce from the 9th Duke of Marlborough in 1921.

Paul-Yves Nizan was a French philosopher and writer.

Marie d'Albret, Countess of Rethel, Countess of Nevers was the suo jure Countess of Rethel, a title which she inherited at the age of nine upon the death of her mother, Charlotte of Nevers, Sovereign Countess of Rethel, on 23 August 1500. She was the wife of Charles II of Cleves, Count of Nevers.

Norbert Dufourcq was a French organist, music educator, musicologist and musicographer.

Charles d'Amboise, Seigneur de Chaumont was a French nobleman, who acted as French governor of Milan (1503–1511) during the reign of Louis XII and as a French commander during the War of the League of Cambrai.

Lubin Baugin was a French painter known for a small number of still lifes, and for religious and mythological paintings.

Bruno Baronchelli is a former professional French football winger.