List of Famous people born in Castile-La Mancha, Spain

Antonio del Rincón was a 15th-century Spanish painter and artist, a court painter to los Reyes Católicos, Ferdinand II of Aragon and Isabella I of Castile.

Tomás Navarro Tomás was a Spanish philologist, librarian and linguist,

Thomas of Villanova, born Tomás García y Martínez, was a Spanish friar of the Order of Saint Augustine who was a noted preacher, ascetic and religious writer of his day. He became an archbishop who was famous for the extent of his care for the poor of his see.

Alfonso Carrillo de Albornoz was a Roman Catholic cardinal.

Juan Bautista Martínez del Mazo was a Spanish Baroque portrait and landscape painter, the most distinguished of the followers of his father-in-law Velázquez, whose style he imitated more closely than did any other artist. A fine painter himself, Mazo was a master of landscape, as proven by his most celebrated work View of Saragossa.

Tomás Gómez-Díaz Roncero, better known as Tomás Roncero, is a Spanish sports journalist. In the written press, he is editor-in-chief of the newspaper As, on radio, he is a member of the commentary team at Carrusel Deportivo on Cadena SER and on television, he is one of the commentators of the program El chiringuito de Jugones.

Jacob Berab, also spelled Berav or Bei-Rav,, was an influential rabbi and talmudist best known for his attempt to reintroduce classical semikhah (ordination).

Alonso de Ojeda was a Spanish explorer, governor and conquistador. He travelled through Guyana, Venezuela, Trinidad, Tobago, Curaçao, Aruba and Colombia. He navigated with Amerigo Vespucci who is famous for having named Venezuela, which he explored during his first two expeditions, for having been the first European to visit Guyana, Curaçao, Colombia, and Lake Maracaibo, and later for founding Santa Cruz.