List of Famous people born in Castile-La Mancha, Spain

Abū Isḥāq Ibrāhīm ibn Yaḥyā al-Naqqāsh al-Zarqālī al-Tujibi ; also known as Al-Zarkali or Ibn Zarqala (1029–1100), was an Arab maker of astronomical instruments and an astrologer from the western part of the Islamic world.

Joseph ben Ephraim Karo, also spelled Yosef Caro, or Qaro, was author of the last great codification of Jewish law, the Shulchan Aruch, which is still authoritative for all Jews pertaining to their respective communities. To this end he is often referred to as HaMechaber and as Maran.

Gonzalo Ruiz de Toledo was a Spanish aristocrat who died in 1323. Best known by the title "Count of Orgaz", he is depicted in a 16th century painting, The Burial of the Count of Orgaz, by El Greco which is widely acknowledged as the artist's masterpiece.

Pedro Pacheco de Villena also known as Pedro Pacheco Ladrón de Guevara, was a Spanish cardinal and viceroy of Naples. In Italian his name is spelled Pietro Pacecco. His nephew Francisco Pacheco de Toledo was also a cardinal.

Francisco de Mora (c.1553–1610) was a Spanish Renaissance architect.

Fernando Niño de Guevara was a Spanish cardinal who was also Archbishop of Seville and Grand Inquisitor of Spain.

Juan de Mariana, also known as Father Mariana, was a Spanish Jesuit priest, Scholastic, historian, and member of the Monarchomachs.

Andrés Pacheco (1550–1626) was a Spanish churchman and theologian.