List of Famous people born in Castile-La Mancha, Spain

Rafael 'Rafa' García García is a Spanish professional footballer who plays for CD Manchego Ciudad Real as a midfielder.

Rahel la Fermosa was a Jewish woman who lived in Toledo, Spain in the twelfth century. She was the paramour of King Alfonso VIII of Castile, a Catholic Christian and husband of Eleanor of England, for almost seven years. Under her influence, a number of Spanish Jews were appointed to positions within the royal court. This led to discontent among the clergy and nobility. Rahel's enemies had her murdered, together with her fellow Jews in the court, in the presence of the king himself.

Andrés de Vandelvira (1509–1575) was a Spanish architect, active mainly in Jaén, Uclés, Baeza, and Úbeda during the Renaissance. He was born in Alcaraz, in the province of Albacete and died in Jaén.

Francisco Aritmendi Criado was a Spanish long-distance runner who competed mainly in cross country running competitions. He was the gold medallist at the 1964 International Cross Country Championships. He was a six-time competitor at the competition and also shared in a team silver in 1962. However, his failure to finish at the 1963 race drew great criticism as Spain missed the team title as a result.

Raúl García de Mateos Rubio is a Spanish racing cyclist. His brother Vicente García de Mateos is also a racing cyclist.

Moses de León, known in Hebrew as Moshe ben Shem-Tov, was a Spanish rabbi and Kabbalist who is considered the composer or redactor of the Zohar. It is a matter of controversy if the Zohar is his own work, or if he took traditions going back to Rabbi Shimon bar Yohai and committed them to writing. His other works include Sefer ha-Rimon, written in Hebrew.

Alfonso Carrillo de Acuña was a Spanish politician and Roman Catholic archbishop.