List of Famous people born in Castile-La Mancha, Spain

Juan Álvarez de Toledo was a Spanish Dominican and Cardinal, from 1538. Considered papabile in the papal conclave (1549–1550), he was initially running second in votes to Reginald Pole. He was again a candidate in 1555.

Alonso de Covarrubias was a Spanish architect and sculptor of the Renaissance, active mainly in Toledo.

Gonzalo Pérez 'Gudiel' (1238/9–1299), simply Gonzalo Pérez during his life, and wrongly Gonzalo García Gudiel in later church tradition, was a Castilian prelate and statesman in the service of kings Alfonso X and Sancho IV and Pope Boniface VIII. He was Bishop of Cuenca (1272) and Burgos (1275) and Archbishop of Toledo (1280), the first official Primate of Spain (1285) and finally Cardinal-bishop of Albano (1298) at the curia Romana. His early career was that of an international scholar, before he settled into royal service.

Nuño Beltrán de Guzmán was a Spanish conquistador and colonial administrator in New Spain. He was the governor of the province of Pánuco from 1525 to 1533 and of Nueva Galicia from 1529 to 1534, President of the first Royal Audiencia of Mexico from 1528 to 1530. He founded several cities in Northwestern Mexico, including Guadalajara.

Isaac Aboab of Castile, also known as Isaac Aboab II, was a Spanish-Jewish Rabbi, Posek and Torah commentator.

Juan Carlos Rodríguez Belencoso is a Spanish footballer who plays for CF Villanovense as a forward.

Abel Resino Gómez, sometimes known just as Abel, is a Spanish retired footballer who played as a goalkeeper, and a manager.