List of Famous people born in Castile and León, Spain

Fernando Cayo is a Spanish actor best known for the role of Colonel Luis Tamayo in Money Heist.

Roberto Heras Hernández is a Spanish former professional road bicycle racer who won the Vuelta a España a record four times. Between 1997 and 2005 he finished in the top 5 of the Vuelta every year except 1998 when he finished 6th. He won a record-tying three times, and then broke the record with a fourth win in 2005, but he was eventually disqualified after being accused of taking EPO. Heras chose to fight the accusations and this resulted in a lengthy court case and appeal process.

Leonor Izquierdo was the muse and wife of the poet Antonio Machado, who met her at the age of thirteen when he was working as a teacher in Soria.

Luis Montes Mieza, was a Spanish anesthetist and pro-euthanasia activist. He was the Federal President of the association "Derecho a Morir Dignamente" from 2009 till his death.

Bernal Díaz del Castillo was a Spanish conquistador, who participated as a soldier in the conquest of Mexico under Hernán Cortés and late in his life wrote an account of the events. As an experienced soldier of fortune, he had already participated in expeditions to Tierra Firme, Cuba, and to Yucatán before joining Cortés. In his later years he was an encomendero and governor in Guatemala where he wrote his memoirs called The True History of the Conquest of New Spain. He began his account of the conquest almost thirty years after the events and later revised and expanded it in response to the biography published by Cortes's chaplain Francisco López de Gómara, which he considered to be largely inaccurate in that it did not give due recognition to the efforts and sacrifices of others in the Spanish expedition.

Pedro Arias de Ávila was a Spanish soldier and colonial administrator. He led the first great Spanish expedition to the mainland of the New World. There he served as governor of Panama (1514–1526) and Nicaragua (1527–1531), and founded Panama City (1519).

Claudio Rodríguez was a Spanish voice actor.

José Jiménez Lozano was a Spanish writer. In 2002 he was awarded the Miguel de Cervantes Prize.

Baltasar Lobo was a Spanish artist, anarchist and sculptor best known for his compositions depicting mother and child.

María Bernabéu Avomo is a Spanish judoka of Equatoguinean descent. She currently competes for Spain, which she represented at the 2016 Summer Olympics.