List of Famous people born in Castile and León, Spain

Isabella, Princess of Asturias was a queen consort of Portugal and heir presumptive of King Ferdinand II of Aragon and Queen Isabella I of Castile, as their eldest daughter. Her younger siblings were John, Prince of Asturias, Queen Joanna I of Castile, Maria, Queen of Portugal and Catherine, Queen of England.

Carmen-Alfonsa-Fernanda-Estrella-Natalena Koroleva was a Ukrainian writer.

Juan de Ayolas was a conquistador born in Briviesca who explored the watershed of the Río de la Plata for the Spanish Crown. He accompanied Pedro de Mendoza on his 1534 expedition to colonize the region between the Río de la Plata and the Strait of Magellan and briefly succeeded him as the second governor of the region after Mendoza returned home in 1537.

Tomás Villanueva Rodríguez was a Spanish politician. He was born in Valladolid and held several positions in the Junta of Castile and León. He was involved in various corruption scandals, and was set to appear before court in late 2017. However, on 7 September 2017, at the age of 64, Villanueva died suddenly of a heart attack.

Álvaro of Córdoba (c.1350–c.1430) was born at Zamora in Spain and entered the Order of Preachers in 1368. He preached throughout Spain and Italy and also established the priory of Scala Caeli at Córdoba where he promoted the regular life. By his preaching and contemplation of the Lord's Passion he spread the practice of the Way of the Cross throughout the West. He died on 19 February 1430. Pope Benedict XIV beatified him in 1741.

Isaac Viciosa is a former middle distance runner from Spain.

Enrique Álvarez Conde was a Spanish academic.

Consuelo Madrigal Martínez-Pereda is a Spanish prosecutor who currently serves as prosecutor in the Spanish Supreme Court. Previously, she served as Attorney General of Spain between January 2015 and November 2016, being the first woman to hold this position.

Fernando García Valverde, better known as Tito Valverde, is a Spanish actor. He is best known for his performance as Gerardo Castilla in the television series El comisario.

Alberto García-Alix is a Spanish photographer from León, Spain. He won the National Photography Award in 1999.