List of Famous people born in Castile and León, Spain

Infante Jaime of Spain, Duke of Segovia, Duke of Anjou,, was the second son of King Alfonso XIII of Spain and his wife Princess Victoria Eugenie of Battenberg. He was born in the Royal Palace of La Granja de San Ildefonso in Segovia Province, and was consequently granted the non-substantive title of "Duke of Segovia", courtesy he held along with "Duke of Anjou" as the Legitimist pretender to the French throne. Jaime was a great-grandchild of Queen Victoria of the United Kingdom.

Julio Bañuelos is a Spanish retired footballer who played as a defender, He has managed clubs including Alavés and Burgos. He was a graduate of the Barcelona academy. He is the former head coach at Persija Jakarta

María del Carmen Hernández Barrera was a Spanish Roman Catholic catechist and the co-founder of the Neocatechumenal Way.

Sergio Escudero Palomo is a Spanish professional footballer who plays for Sevilla FC as a left back.

García II, King of Galicia and Portugal, was the youngest of the three sons and heirs of Ferdinand I, King of Castile and León, and Sancha of León, whose Leonese inheritance included the lands García would be given. Garcia first appears in an 11 September 1064 settlement with Suero, Bishop of Mondoñedo, his father confirming the agreement.

Antonio Vallejo-Nájera (1889–1960) was a Spanish psychiatrist. He was interested in eugenics and proposed a link between Marxism and mental retardation. It is suspected that 30,000 children were taken from socialist families and placed with fascist families. Vallejo-Nájera was rewarded for his assistance during the Spanish Civil War and he became a leading figure in Spanish psychiatry.

Óscar Puente Santiago is a Spanish politician and advocate. Óscar Puente is a member of the Spanish Socialist Workers' Party. He is the current Mayor of Valladolid since 2015. He was the President of the Socialist Group at the City Council of Valladolid, in office from 11 July 2008 to 13 June 2015. He is the current spokesman of the federal executive of the Spanish Socialist Workers' Party since 2017. He was elected secretary general of the local socialist group and in 2010, the municipal and provincial executives supported him as a candidate for mayor of Valladolid in 2009. He is the also current councilor of the Valladolid city from 16 June 2007. He has been a lawyer since 1995.

Leopoldo Enrique García-Alas y Ureña, also known as Clarín, was a Spanish realist novelist born in Zamora. His inflammatory articles, known as paliques (“chitchat”), as well as his advocacy of liberalism and anti-clericalism, made him a formidable and controversial critical voice. He died in Oviedo.

Sergio Asenjo Andrés is a Spanish professional footballer who plays for Villarreal as a goalkeeper.

Alfonso Fernández Mañueco is a Spanish politician who serves as the President of the Junta of Castile and León since 2019. He is also the chairman of the People's Party of Castile and León since 2017. He served as Mayor of Salamanca between 2011 and 2018.