List of Famous people born in Castile and León, Spain

Paul B. Preciado, is a writer, philosopher and curator whose work focuses on applied and theoretical topics relating to identity, gender, pornography, architecture and sexuality. In 2010, Preciado began a process of "slow transition" where he started the process of becoming a male, physically. From this point on he has considered himself transgender as well as a feminist.

Isabel García Tejerina is a Spanish politician who is a member of the PP. She has a Master's from University of California, Davis in Agricultural Economy, a Bachelor's in Law from the University of Valladolid and a degree in agricultural engineering from the Technical University of Madrid. She has been General Secretary of Agriculture and Feeding of Spain for two periods: from April 2000 to April 2004 and from February 2012 to April 2014. She was Spain's Minister of Agriculture, Fishers, Food and Environment from 28 April 2014 until 1 June 2018, when a vote of no-confidence against Mariano Rajoy ousted the government. Her re-appointment caused some criticism by Spanish environmentalists.

Elvira Sastre Sanz is a Spanish writer, poet, philologist, and literary translator.

Jesús López Cobos was a Spanish conductor.

Andrés Trapiello is a noted Spanish poet and writer. He was born in Manzaneda de Torío, León, and studied at the University of Valladolid. He moved to Madrid in 1975, and has lived in the capital ever since.

José Luis García Sánchez is a Spanish film director, screenwriter and producer. He has directed 30 films since 1968. He wrote for the 1973 film Habla, mudita, which was entered into the 23rd Berlin International Film Festival. In 1978, he directed Las truchas ("Trouts"), which won the Golden Bear at the 28th Berlin International Film Festival.

Dionisio Ridruejo Jiménez was a Spanish poet and political figure associated with the Generation of '36 movement and a member of the Falange political party. He was co-author of the words to the Falangist anthem Cara al Sol. In later years he fell from favour with the Francoist State and eventually became associated with opposition groups.

Diego Marín Aguilera (1757–1799) was a Spanish inventor who was an early aviation pioneer.

Fermín Cacho Ruiz is a Spanish track and field athlete, winner of the gold medal in the 1500m at the 1992 Summer Olympics in Barcelona and the silver medal in the 1500m at the 1996 Summer Olympics in Atlanta.

Miguel Ángel Rodríguez Bajón, often going by the MAR acronym, is a Spanish politician, publicist, media consultant and journalist.