List of Famous people with last name Guise

Henry I, Prince of Joinville, Duke of Guise, Count of Eu, sometimes called Le Balafré (Scarface), was the eldest son of Francis, Duke of Guise, and Anna d'Este. His maternal grandparents were Ercole II d'Este, Duke of Ferrara, and Renée of France. Through his maternal grandfather, he was a descendant of Lucrezia Borgia and Pope Alexander VI.

Francis de Lorraine II, the first Prince of Joinville, also Duke of Guise and Duke of Aumale, was a French general and politician. A prominent leader during the Italian War of 1551–1559 and French Wars of Religion, he was assassinated during the siege of Orleans in 1563.

Prince Jean of Orléans, Duke of Guise, was the third son and youngest child of Prince Robert, Duke of Chartres (1840–1910), grandson of Prince Ferdinand Philippe and great-grandson of Louis Philippe I, King of the French. His mother was Françoise of Orléans, daughter of François, Prince of Joinville, and Princess Francisca of Brazil.

Claude de Lorraine, duc de Guise was a French aristocrat and general. He became the first Duke of Guise in 1528.

Charles de Lorraine, 4th Duke of Guise and 3rd Prince of Joinville, was the son of Henry I, Duke of Guise and Catherine of Cleves, and succeeded his father as Duke of Guise in 1588. Initially part of the Catholic league, he pledged his support for Henry IV of France and was made Admiral of the Levant by Louis XIII of France. After siding with the Queen Mother, Marie de' Medici, against Cardinal Richelieu, he fled to Italy with his family where he died in 1640.

Louis II, Cardinal of Guise, was the third son of Francis, Duke of Guise, and Anna d'Este.

Louis de Lorraine was the fourth son of Claude, Duke of Guise and Antoinette de Bourbon, and the younger brother of Charles of Guise, Cardinal of Lorraine, and Mary of Guise, queen consort of King James V of Scotland. He was the nephew of Cardinal Jean de Lorraine. He is sometimes known as the cardinal de Guise.