List of Famous people born in Western Cape, South Africa

Stefan Temmingh is a South African recorder player who now lives in Munich.

Sylvia Raphael Schjødt was a South African-born Israeli Mossad agent, convicted of murder in Norway for her involvement in the Lillehammer affair.

Sir Ronald Harwood, was a South African-born British author, playwright, and screenwriter, best known for his plays for the British stage as well as the screenplays for The Dresser and The Pianist, for which he won the 2003 Academy Award for Best Adapted Screenplay. He was nominated for the Best Adapted Screenplay Oscar for The Diving Bell and the Butterfly (2007).

Resident Evil: The Final Chapter is a 2016 science fiction action film written and directed by Paul W. S. Anderson. A direct sequel to Resident Evil: Retribution (2012), it is the sixth installment in the Resident Evil film series, which is based on the video game series of the same name. The film stars Milla Jovovich, Iain Glen, Ali Larter, Shawn Roberts, Eoin Macken, Fraser James, Ruby Rose, Rola, and William Levy. In the film, Alice and her friends are betrayed by a clone of Albert Wesker, who gathers the entire forces of Umbrella into one final strike against the apocalypse survivors.

Johann Peter Rupert is a South African-born entrepreneur, who is the eldest son of business tycoon Anton Rupert and his wife Huberte. He is the chairman of the Swiss-based luxury-goods company Richemont and the South Africa-based company Remgro. As of 1 April 2010, he assumed the CEO position of Compagnie Financiere Richemont. Together with his family, he was estimated to be worth $5.9 billion as of April 2019, and was ranked as the second wealthiest person in South Africa on the Forbes list of The World's Billionaires of 2019, with his fortune reported as having declined from US$7.3 billion. Rupert and family were ranked as the second-richest in South Africa on the 2020 Forbes list, with a fortune reported as US$5.4 billion.

Princess Irene of Greece and Denmark is the youngest child and second daughter of King Paul of Greece and his wife Queen Frederica. She is the younger sister of Queen Sofía of Spain and of the deposed King Constantine II of Greece, Prince of Denmark and maternal aunt of king Felipe VI of Spain.

Alice Phoebe Lou is a South African singer-songwriter. She has released three EPs and two studio albums. In December 2017 her song "She" from the film Bombshell: The Hedy Lamarr Story was included on the Oscars shortlist for Best Original Song. Since 2019 she had also been active in her side project Strongboi.

Benedict Saul "Benni" McCarthy is a South African coach and former footballer who was appointed head coach of the Durban based PSL team, AmaZulu Football Club on 14 December 2020.

Johan van Zyl Steyn, Baron Steyn, PC was a South African-British judge, until September 2005 a Law Lord. He sat in the House of Lords as a crossbencher.

Louis Tebogo Moholo, is a South African jazz drummer. He has been a member of several notable bands, including The Blue Notes, the Brotherhood of Breath and Assagai.