List of Famous people born in Tolima Department, Colombia

Gilberto José Rodríguez Orejuela is a Colombian former drug lord, who once was one of the leaders of the Cali Cartel, based in the city of Cali.

Miguel Ángel Rodríguez Orejuela is a Colombian drug lord, formerly one of the leaders of the Cali Cartel, based in the city of Cali. He is the younger brother of Gilberto Rodríguez Orejuela. He married Miss Colombia 1974, Marta Lucía Echeverry.

Pedro Alonso López is a Colombian serial killer and child killer, who was sentenced for killing 110 girls, but who claimed to have raped and killed more than 300 girls across Colombia, Peru and Ecuador. Aside from uncited local accounts, López's crimes first received international attention from an interview conducted by Ron Laytner, a longtime freelance photojournalist who reported interviewing López in his Ambato prison cell in 1980.

Manuel Elkin Patarroyo Murillo is a Colombian Professor of Pathology and Immunology who made the world's first attempt to create a synthetic vaccine against a parasite called the protozoa Plasmodium falciparum that causes severe malaria, a disease that causes death in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.

Alberto Santofimio Botero is a Colombian politician, a member of the Colombian Liberal Party. He has been Minister of Justice, a two-time presidential candidate and a Senator. He was considered to be a sure bet for president in 1982, but he decided to let his boss, Alfonso López Michelsen who had been President from 1974 to 1978, run for reelection. In the 1990s, Santofimio was involved in the campaign Process 8000 as head of the Liberal Party in Tolima Department as that party's office was accused of receiving money from companies part of an investigation in order to support the campaign for the presidency of Colombia for Ernesto Samper.

Jorge Barón is a Colombian television presenter, media personality and businessman.

Juan Carlos Echeverry Garzón is a Colombian economist and former president of Ecopetrol, an oil and gas company. He served as the 68th Minister of Finance and Public Credit of Colombia from 2010 to 2012. He is the president of Econcept, a financial consulting firm in Bogotá and is an Associate Professor of Economics at University of the Andes. He was also a visiting professor at IE Business School, Madrid in 2013.

Hernán Torres Oliveros is a Colombian football manager and retired goalkeeper who is the current manager of Deportes Tolima.

Henry Andres Rojas Delgado is a Colombian footballer who currently plays as a midfielder for Atlético Bucaramanga in the Categoria Primera A.

Santiago Cruz Vélez is a Colombian singer and songwriter.