List of Famous people born in South Carolina, United States of America

Whitley David Merrifield is an American professional baseball second baseman, right fielder, center fielder, and left fielder for the Kansas City Royals of Major League Baseball (MLB).

William Ford Gibson is an American-Canadian speculative fiction writer and essayist widely credited with pioneering the science fiction subgenre known as cyberpunk. Beginning his writing career in the late 1970s, his early works were noir, near-future stories that explored the effects of technology, cybernetics, and computer networks on humans—a "combination of lowlife and high tech"—and helped to create an iconography for the information age before the ubiquity of the Internet in the 1990s. Gibson coined the term "cyberspace" for "widespread, interconnected digital technology" in his short story "Burning Chrome" (1982), and later popularized the concept in his acclaimed debut novel Neuromancer (1984). These early works of Gibson's have been credited with "renovating" science fiction literature in the 1980s.

Harry Donald Carson is a former American football inside linebacker who played his entire professional career for the New York Giants of the National Football League (NFL). Carson was inducted into the College Football Hall of Fame in 2002 and the Pro Football Hall of Fame in 2006.

Leeza Kim Gibbons is an American talk show host. She is best known as a correspondent and co-host for Entertainment Tonight (1984–2000) as well as for having her own syndicated daytime talk show, Leeza (1993–2000). In 2013, her book Take 2 became a New York Times bestseller and she won the Daytime Emmy for Outstanding Host in a Lifestyle or Travel program for the PBS show, My Generation. On February 16, 2015, Leeza was named the winner of Celebrity Apprentice, having raised $714,000 for her charity Leeza's Care Connection.

Robin Stender Swicord is an American screenwriter and film director. She is best known for literary adaptations. In 2009 the screenplay for The Curious Case of Benjamin Button, credited to Swicord (story) and Eric Roth and based on the short story by F. Scott Fitzgerald, was nominated for the Academy Award for Best Adapted Screenplay and the Golden Globe Award for Best Screenplay. Swicord also wrote the screenplay for the film Memoirs of a Geisha, based on the novel of the same name by Arthur Golden, for which she won a 2005 Satellite Award. Her other screenplay credits include Little Women, Practical Magic, Matilda, The Perez Family, and Shag.

Virginia Inman Postrel is an American political and cultural writer of broadly libertarian, or classical liberal, views. She is a recipient of the Bastiat Prize (2011).

Judith Chapman is an American actress, best known for soap opera roles, particularly as Natalie Bannon Hughes in As the World Turns, Charlotte Greer on Ryan's Hope, Ginny Blake Webber on General Hospital, Sandra Montaigne on One Life to Live, Anjelica Deveraux Curtis on Days of Our Lives, and Gloria Abbott Bardwell on The Young and the Restless.

Helen Chandler was an American film and theater actress, best known for playing Mina Seward in the 1931 horror film Dracula.

Johnny Whitworth is an American actor. He is known for his roles as A.J. in Empire Records (1995), as Donny Ray Black in Francis Ford Coppola's The Rainmaker (1997), as Vernon Gant in Limitless (2011), as Blackout in the Marvel superhero film Ghost Rider: Spirit of Vengeance (2011), and as Cage Wallace in The CW's series The 100.

Devin Booker is an American professional basketball player for Khimki of the VTB United League and the EuroLeague.