List of Famous people born in Santiago Metropolitan Region, Chile

Felipe Ignacio Seymour Dobud is a Chilean professional footballer who playes as a defensive midfielder for Chilean Primera División club O'Higgins.

José Manuel Rojas Bahamondes, known as José Rojas, is a Chilean footballer who currently plays for Curicó Unido. Primarily a central defender, he can also be deployed as a left-back.

Javiera Cereceda Orrego, better known as Javiera Parra, is a Chilean musician and singer born in Santiago. She is the lead singer of rock band Javiera y Los Imposibles. A third generation member of Chile's Parra family, known for its many musicians, she is the granddaughter of famous Chilean folklorist Violeta Parra. Her brother Ángel Parra is a member of rock group Los Tres.

Luis Arturo Zúñiga Jory is a Chilean politician who served as Undersecretary of Assistance Networks. Zúñiga served as chief of staff for health minister Jaime Mañalich during the first term of president Sebastián Piñera and as health director for the commune of Panguipulli.

Carlos Humberto Caszely Garrido is a Chilean former footballer, nicknamed "Rey del metro cuadrado", who played as a forward.

Maria Soledad Onetto is a Chilean TV presenter. She is a journalism graduate from the Pontifical Catholic University of Chile, news reader and TV host Chile. She is married to Rodrigo Alonso.

Roberto Farías Morales is a Chilean actor. He has appeared in more than thirty films since 2003. He also works in dubbing.

Cristián Precht Bañados is a Chilean Catholic former priest, known for his work during the military dictatorship in defense of human rights. He was vicar of the Vicariate of Solidarity between 1976 and 1979. In September 2018, he was laicized for his participation in cases of child sexual abuse.

Christian Alberto Vilches González, known as Christian Vilches, is a Chilean professional footballer who plays as a central defender for Unión La Calera.

Alfredo Castro is a Chilean actor. He has appeared in more than fifty films since 1982.