List of Famous people born in Santiago Metropolitan Region, Chile

Benjamín Ignacio Galdames Millán is a Mexican professional footballer who plays as a midfielder for Chilean Primera División club Unión Española.

Diego Alfonso Valdés Contreras is a Chilean footballer who currently plays for Liga MX club Santos Laguna and the Chile national team as an attacking midfielder.

Felipe José Kast Sommerhoff is a Chilean economist, Researcher, consultant and politician.

Axel Phillip Kaiser Barents-Von Hohenhagen is a Chilean writer, lawyer and political scientist.

María José de Pablo Fernández, known professionally as Cote de Pablo, is a Chilean-American actress and singer. Born in Santiago, Chile, at the age of ten she moved to the United States, where she studied acting.

Verónica Michelle Bachelet Jeria is a Chilean politician who has served as United Nations High Commissioner for Human Rights since 2018. She also previously served as President of Chile from 2006 to 2010 and 2014 to 2018 for the Socialist Party of Chile, she is the first woman to hold the Chilean presidency. After leaving the presidency in 2010 and while not immediately reelectable, she was appointed the first executive director of the newly created United Nations Entity for Gender Equality and the Empowerment of Women. In December 2013, Bachelet was reelected with over 62% of the vote, bettering the 54% she obtained in 2006. She was the first President of Chile to be reelected since 1932.

Daniela Vega Hernández is a Chilean actress and mezzo-soprano singer. She is best known for her critically acclaimed performance in the Academy Award-winning film A Fantastic Woman (2017). At the 90th Academy Awards in 2018, Vega became the first transgender person in history to be a presenter at the Academy Awards ceremony. In 2018, Time magazine named her one of the 100 most influential people in the world.

Cecilia Carolina Bolocco Fonck is a Chilean actress, TV Host and beauty queen who was crowned Miss Universo Chile 1987 and Miss Universe 1987.

Gary Alexis Medel Soto is a Chilean professional footballer who plays for Italian club Bologna as a defensive midfielder. However, he can also play as a defender, and has even been deployed as a centre-back throughout his career, as well as in midfield. Medel has played club football with several teams in numerous countries, starting out with Chilean side Universidad Católica, and later playing for Argentine side Boca Juniors, Spanish side Sevilla, Premier League side Cardiff City, and Italian side Inter Milan, before moving to Beşiktaş in Turkey in 2017. He then moved back to Italy and joined Bologna FC 1909 in 2019.

Lorenza Francesca Izzo Parsons is a Chilean actress and model. She has appeared in films, including Aftershock (2012), The Green Inferno (2013), Knock, Knock (2015), and Once Upon a Time in Hollywood (2019).