List of Famous people born in Santiago Metropolitan Region, Chile

Nicole Elizabeth LaValle, best known by her nickname Snooki, is an American reality television personality. She is best known for being a cast member of the MTV reality show Jersey Shore and starring in Snooki & Jwoww and Jersey Shore: Family Vacation. Since appearing on Jersey Shore in 2009, Snooki has gained popularity, leading to numerous talk show appearances, web and television series participation and hosting, and a large social media following. She reportedly earned $150,000 per Jersey Shore episode by the last season. She also appeared as the guest hostess for WWE Raw in 2011 and competed at WrestleMania XXVII that same year.

Mauricio Aníbal Isla Isla is a Chilean footballer who currently plays for Brazilian Série A club Flamengo and for the Chile national team.

Jean André Emanuel Beausejour Coliqueo is a Chilean professional footballer who plays as a left-sided wing-back for Primera División club Universidad de Chile.

Paula Graciela Daza Narbona is a Chilean surgeon, pediatrician and politician who served as Undersecretary of Public Health. Daza was a consultant for Evelyn Matthei and Andrés Allamand during the 2013 Chilean general election partly drafting the health care plan of their presidential campaigns. During the COVID-19 pandemic a criminal complaint was filed against Daza and other members of the government, which accused them of negligence during the pandemic.

Benjamín Kuscevic Jaramillo is a Chilean footballer who currently plays for Palmeiras as a centre-back.

Claudia Christiane Endler Mutinelli is a Chilean professional footballer who plays as goalkeeper for Paris Saint-Germain and the Chile women's national team. She is widely regarded as one of the top goalkeepers in the world.

Alejandro Fernando Amenábar Cantos is a Spanish-Chilean film director, screenwriter and composer. Among other honors, he has won nine Goyas and two European Film Awards and one Academy Award. He has written the screenplays to all six of his films and composed almost all of their soundtracks.

Francisco Andrés Sierralta Carvallo is a Chilean professional footballer who plays as defender for Premier League club Watford and the Chile national team.

Daniela Paz Castillo Vicuña is a Chilean female pop singer and actress born in Santiago. She debuted in 2002 as a solo artist on the Chilean TV show Rojo: Fama Contra Fama. She studied four years at the Alicia Puccio Academy where she met the casting crew for the TV show Rojo. Although she did not win first place in the singer talent contest, she became very popular due to her voice.

Rafael Andrés Olarra Guerrero is a former footballer who played as a defender.