List of Famous people born in Santiago del Estero Province

Alfredo David "Chango" Moreno was an Argentine footballer who last played as a forward for Celaya F.C. of the Ascenso MX.

Óscar Guido Trejo is an Argentine professional footballer who plays for Spanish club Rayo Vallecano as a forward.

Petrona Carrizo de Gandulfo, better known as Doña Petrona, was an Argentine best-selling cookbook author, home economist, television chef and businesswoman who was famous for "her elaborate dishes, provincial accent, matronly figure, didactic tone, and bossy treatment of her assistant [Juana Bordoy], as well as her responsiveness to fans". Although recognized as "the most famous Argentine cook", she was quoted as saying in 1985: "I never wanted to be anything other than a [home economist]. No one, except my friends, can say that they had Doña Petrona in their kitchen at any time."

René Orlando Houseman, nicknamed Loco, was an Argentine footballer, who played as a right winger. At the beginning of his career, Houseman was considered successor of legendary winger Omar Corbatta, being still regarded by many sports journalists as one of the best Argentine wingers ever.

Leopoldo Dante Tévez, known as Leo Dan, is an Argentine composer and singer born in Villa Atamisqui, Santiago del Estero Province. He recorded more than 20 albums during his long career during the late 20th century between Argentina and Mexico. His appreciation for Mexican music led him to record with mariachis, and from there he went to international fame. His music was well received by the Mexican public since his voice was a good match to the traditional mariachi sound.

Gabriel Alejandro "Gaby" Deck is an Argentinian professional basketball player for Real Madrid of the Liga ACB and EuroLeague. At a height of 1.99 m, he can play at both the small forward and power forward positions.

Ramón Carrillo, was an Argentine neurosurgeon, neurobiologist, physician, academic, public health advocate, and from 1949 to 1954 the nation's first Minister of Health.

Julio Ricardo Cruz is an Argentine former footballer. He played for clubs in Argentina, the Netherlands and Italy before retiring in 2010. The longest spell of his career was spent with Internazionale, with whom he won four consecutive Serie A titles, among other honours. A large and physical player, who was known for his ability in the air, he usually played as a striker but he has even played as a winger, as an attacking midfielder, and as a centre-forward. In 2015, he opened his own charity foundation, the Julio Cruz Foundation.

Omar Sebastián Pérez Marcos is an Argentine retired footballer who played as a midfielder.

José Luis Gómez is an Argentine footballer who plays as a right back for Primera División de Argentina club Lanús. In 2014, he won the league with Racing Club.