List of Famous people born in Prague, Czech Republic

Václav Klaus is a Czech economist and politician who served as the second president of the Czech Republic from 2003 to 2013. From July 1992 until the dissolution of Czechoslovakia in January 1993, he served as the second and last prime minister of the Czech Republic while it was a federal subject of the Czech and Slovak Federative Republic, and then as the first prime minister of the newly independent Czech Republic from 1993 to 1998.

Sigismund of Bohemia, also known as Sigismund of Luxembourg, was prince-elector of Brandenburg from 1378 until 1388 and from 1411 until 1415, king of Hungary and Croatia from 1387, king of Germany from 1411, king of Bohemia from 1419, king of Italy from 1431, and Holy Roman Emperor from 1433 until 1437, and the last male member of the House of Luxembourg.

Also known as John of Bohemia and John of Luxembourg, was a member of the House of Luxembourg and the only Duke of Görlitz (Zgorzelec) from 1377 until his death.

Jan Kaplický was a Neofuturistic Czech architect who spent a significant part of his life in the United Kingdom. He was the leading architect behind the innovative design office, Future Systems. He was best known for the neofuturistic Selfridges Building in Birmingham, England, and the Media Centre at Lord's Cricket Ground in London.

Jan Kasl is a Czech politician and former Mayor of the City of Prague and one of the leaders of the SNK European Democrats.

Antonín Holý was a pioneering Czech scientist. He specialised in the field of chemistry and cooperated on the development of important antiretroviral drugs used in the treatment of HIV and hepatitis B. He was involved in the creation of the most effective drug in the treatment of AIDS. Antonín Holý is the author of more than 400 scientific discoveries and holds 60 patents. With more than 400 discoveries to his credit, his work has affected millions of people with viral diseases such as HIV/AIDS and hepatitis B and many other viral diseases. In 2008 he received an Honorary Professorship at the University of Manchester's School of Chemistry.

Soběslav II, called Prince of the Peasants or King of the Peasants, was the Duke of Bohemia from 1173 to 1178. He was the second son of Soběslav I. Supported by neither nobles nor emperor, he was backed solely by the lowest classes.

Nicolaus of Luxemburg was Patriarch of Aquileia from 1350 until 1358.

Berta Foersterová was a Czech operatic soprano active in Germany. The wife of composer Josef Bohuslav Foerster, she met him while appearing at the Hamburg State Opera. She created the role of Desdemona in the Czech premiere of Giuseppe Verdi's Otello, and sang Tatiana in the Czech premiere of Pyotr Ilyich Tchaikovsky's Eugene Onegin; she also appeared in the world premiere of Antonín Dvořák's The Jacobin.

Barbara Coudenhove-Kalergi is an Austrian journalist. A member of the Coudenhove-Kalergi family, she is the daughter of Gerolf von Coudenhove-Kalergi and thus the niece of Richard von Coudenhove-Kalergi. As ethnic German she was expelled from her hometown Prague during the ethnic cleansing of 1945/1946 that murdered or drove from their homes the more than 30% ethnic Germans, citizens of pre-war Czechoslovakia, from the territories of the country. She was awarded the Order of Tomáš Garrigue Masaryk, Class IV, in 2001.