List of Famous people born in Pottsville, United States of America

Megan Jane Brennan served as the seventy-fourth Postmaster General of the United States. Brennan became the first woman to hold the office when she assumed the position on February 1, 2015.

Ann "Muffet" McGraw is an American former college basketball coach, who served as the head women's basketball coach at Notre Dame from 1987 to 2020, compiling a 905–272 (.769) record over 32 seasons. She led her team to nine Final Fours, seven championship game appearances, and two National Championships in 2001 and 2018.

Ralph Peters is a retired United States Army lieutenant colonel and author.

Gary Stanley Becker was an American economist who received the 1992 Nobel Memorial Prize in Economic Sciences. He was a professor of economics and sociology at the University of Chicago, and was a leader of the third generation of the Chicago school of economics.

John Henry O'Hara was one of America's most talented and prolific writers of short stories, credited with helping to invent The New Yorker magazine short story style. He became a best-selling novelist before the age of 30 with Appointment in Samarra and BUtterfield 8. His work is stands out from that of his contemporary authors for its unvarnished realism. While O'Hara's legacy as a writer is debated, his champions rank him highly among the under-appreciated and unjustly neglected major American writers of the 20th century. Few college students educated after O'Hara's death in 1970 have discovered him, chiefly because he refused to allow his work to be reprinted in anthologies used to teach literature at the college level.

Ronald William Gainer is an American prelate of the Roman Catholic Church. He is the eleventh and current Bishop of Harrisburg, in Harrisburg, Pennsylvania. He previously served as the second Bishop of Lexington in Kentucky, before being named to Harrisburg.