List of Famous people born in Pennsylvania, United States of America

Quinton Jefferson is an American football defensive end for the Buffalo Bills of the National Football League (NFL). He was drafted by the Seattle Seahawks in the fifth round of the 2016 NFL Draft. He played college football at Maryland.

Brandon Eric Guyer is an American former professional baseball outfielder. He played in Major League Baseball (MLB) for the Tampa Bay Rays and Cleveland Indians. His knack for getting hit by pitches earned him the nickname, "La Piñata."

Susan Hannah Macdowell Eakins was an American painter and photographer. Her works were first shown at the Pennsylvania Academy of Fine Arts, where she was a student. She won the Mary Smith Prize there in 1879 and the Charles Toppan prize in 1882. One of her teachers was the artist Thomas Eakins, who later became her husband. She made portrait and still life paintings. She was also known for her photography. After her husband died in 1916, Eakins became a prolific painter. Her works were exhibited in group exhibitions in her lifetime, though her first solo exhibition was held after she died.

Andrew Jay Hertzfeld is an American software engineer and innovator who was a member of the original Apple Macintosh development team during the 1980s. After buying an Apple II in January 1978, he went to work for Apple Computer from August 1979 until March 1984, where he was a designer for the Macintosh system software. Since leaving Apple, he has co-founded three companies: Radius in 1986, General Magic in 1990, and Eazel in 1999. In 2002, he helped Mitch Kapor promote open source software with the Open Source Applications Foundation. Hertzfeld worked at Google from 2005 to 2013, where in 2011, he was the key designer of the Circles user interface in Google+.

Jeffrey M. Beltzner known by his ring name Brick Bronsky, was an American actor, film producer, professional wrestler and sports promoter. He gained particular notoriety for starring in a string of films for Troma Studios during the early-1990s, most notably, in Sgt. Kabukiman N.Y.P.D. (1990), Class of Nuke 'Em High 2: Subhumanoid Meltdown (1991), and Class of Nuke 'Em High 3: The Good, the Bad and the Subhumanoid (1994); he also had a small role in Jean-Claude Van Damme's The Quest (1996).

Nick Adams was an American film and television actor and screenwriter. He was noted for his roles in several Hollywood films during the 1950s and 1960s along with his starring role in the ABC television series The Rebel (1959). Decades after Adams' death from a prescription drug overdose at the age of 36, his widely publicized friendships with James Dean and Elvis Presley would stir speculation about both his private life and the circumstances of his death. In an AllMovie synopsis for Adams' last film, reviewer Dan Pavlides wrote, "Plagued by personal excesses, he will be remembered just as much for what he could have done in cinema as what he left behind."

Mary Hardy Reeser of St. Petersburg, Florida, was a suspected victim of spontaneous human combustion.

Carl Thomas Keifer is an American vocalist, guitarist, and primary songwriter for the band Cinderella.

Justin Andrew Honard is an American drag performer and recording artist known by the stage name Alaska Thunderfuck 5000, primarily known mononymously as Alaska, best known as the runner-up on the fifth season of RuPaul's Drag Race and the winner of the second season of RuPaul's Drag Race All Stars. In June 2019, a panel of judges from New York magazine placed her seventh on their list of "the most powerful drag queens in America", a ranking of 100 former Drag Race contestants.

Ian Edward Happ is an American professional baseball outfielder for the Chicago Cubs of Major League Baseball (MLB). He played college baseball at the University of Cincinnati for the Cincinnati Bearcats baseball team. The Cubs selected Happ in the first round of the 2015 MLB draft, and he made his MLB debut in 2017.