List of Famous people born in Pennsylvania, United States of America

Khama Worthy is an American mixed martial artist who competes in the Lightweight division of the Ultimate Fighting Championship. He was the inaugural 247 Fighting Championship lightweight champion.

Robert F. "Bob" Colesberry Jr. was an American film and television producer, best known as a co-creator of the television series The Wire (2002–2008) for HBO, executive producer of the miniseries The Corner (2000), and a producer for Martin Scorsese's After Hours (1985), Alan Parker's Mississippi Burning (1988), and Billy Crystal's 61* (2001). Colesberry was also an occasional actor.

Shanice Lorraine Wilson-Knox, better known simply as Shanice, is an American singer–songwriter, actress and dancer. Wilson had the Billboard hit singles "I Love Your Smile" and "Silent Prayer" in 1991 and "Saving Forever for You" in 1993. In 1999, Wilson scored another hit song, "When I Close My Eyes", which peaked at No. 12 on Billboard's Hot 100 chart. Wilson is recognized for her coloratura soprano voice and her ability to sing in the whistle register.

Paul Joseph Weitz was an American naval officer and aviator, aeronautical engineer, test pilot, and NASA astronaut, who flew into space twice. He was a member of the three-man crew who flew on Skylab 2, the first crewed Skylab mission. He was also Commander of the STS-6 mission, the maiden flight of the Space Shuttle Challenger.

Alferd Griner Packer, also known as "The Colorado Cannibal", was an American prospector and self-proclaimed professional wilderness guide who confessed to cannibalism during the winter of 1874. He and five other men had attempted to travel through the San Juan Mountains of Colorado, during the peak of a harsh winter. When only Packer reached civilization, he said that he had been abandoned by his party, but eventually confessed that the party had resorted to forced cannibalism of dead members to stay alive when they became lost. He later recanted this story, and confessed to having singularly lived off the flesh of his companions, during his snowbound state – after they had fallen victim to party member Shannon Bell, whom Packer said he shot in self-defense. He confessed to having used their flesh to survive, while stranded and during his trek out of the mountains, nearly two and a half months later.

William V. Lazor is an American football coach and former player who is the offensive coordinator for the Chicago Bears of the National Football League (NFL). Lazor has previously served as the quarterbacks coach for the Washington Redskins, Seattle Seahawks, and Philadelphia Eagles. He is also the former offensive coordinator of the Miami Dolphins and Cincinnati Bengals. He played college football as a quarterback for Cornell University from 1991 to 1993.

Tim Lewis is an American football coach and former player. He played college football for the University of Pittsburgh and was drafted by the Green Bay Packers of the National Football League (NFL) in the first round of the 1983 NFL Draft. Following a neck injury that cut his playing career short after four seasons, he began serving as a coach in the collegiate and professional levels and obtained his first head coaching position with the Birmingham Iron of the Alliance of American Football (AAF) in 2019. He currently serves as the defensive backs coach for the St. Louis BattleHawks of the XFL.

Francis Joseph Dunphy is a former American college basketball coach. He is the former men's basketball coach at Temple University and the University of Pennsylvania. He succeeded John Chaney in 2006 and was succeeded by Aaron McKie in 2019. In June 2020, Dunphy was named interim athletic director of Temple.

William R. Knight is an American former professional basketball player and executive. Playing with the Indiana Pacers in both the American Basketball Association (ABA) and later the National Basketball Association (NBA), he was both an ABA and NBA All-Star. He played college basketball with the Pittsburgh Panthers, who retired his No. 34.

Brian O'Grady is an American professional baseball center fielder and first baseman for the Saitama Seibu Lions of Nippon Professional Baseball (NPB). He has played in Major League Baseball (MLB) for the Cincinnati Reds, Tampa Bay Rays and San Diego Padres.