List of Famous people born in Pennsylvania, United States of America

Scott Jay "Doc" Horowitz is a retired American astronaut and a veteran of four space shuttle missions.

Steven M. Rales is an American businessman, film producer and chairman of Danaher Corporation. In 2018 Forbes listed him as the 88th richest person in America, with a net worth of $6.2 billion.

Twink Caplan is an American actress, comedian, and producer. She is probably best known for her roles in the box office hits Clueless and the Look Who's Talking series. As a producer, her best-known projects were Clueless and its television spin-off.

John Martin Dougherty is a retired American prelate of the Roman Catholic Church who served as the auxiliary bishop of Scranton, Pennsylvania, from 1995 until his resignation was accepted by Pope Benedict XVI on August 31, 2009.

John Jay McCloy was an American lawyer, diplomat, banker, and a presidential advisor. He served as Assistant Secretary of War during World War II under Henry Stimson, helping deal with issues such as German sabotage, political tensions in the North Africa Campaign, and opposing the atomic bombings of Hiroshima and Nagasaki. After the war, he served as the president of the World Bank, U.S. High Commissioner for Germany, chairman of Chase Manhattan Bank, chairman of the Council on Foreign Relations, a member of the Warren Commission, and a prominent United States adviser to all presidents from Franklin D. Roosevelt to Ronald Reagan.

James Patrick Green is an American prelate of the Catholic Church who has been Apostolic Nuncio to several Scandinavian countries since 2017.

Harold Theo Hunter III is an American football coach was the offensive line coach for the New York Giants of the National Football League (NFL). He has previously served as offensive line coach for the Cleveland Browns, Indianapolis Colts and San Diego Chargers. In 1999, he served as the head coach of LSU for one game, a 35–10 win over rival Arkansas, after Gerry DiNardo was fired. He was replaced when LSU hired Nick Saban in 1999.

Christian Joseph Raab, better known by his stage name Raab Himself, is an American television personality, known as a former member of the CKY Crew featured in the MTV series Viva La Bam and Jackass.

John Herbert Adler was an American lawyer, politician and a member of the Democratic Party who served for one term as the U.S. Representative for New Jersey's 3rd congressional district from 2009 until 2011. He lost his 2010 congressional election to former Philadelphia Eagles football player Jon Runyan. Prior to joining Congress, Adler was a member of the New Jersey Senate from 1992 to 2009, where he represented the 6th Legislative District.

James Clifford Timlin is an American prelate of the Catholic Church. He served as Bishop of Scranton from 1984 to 2003. During his tenure as bishop, he reassigned a priest who had raped a girl and arranged for her family to be paid to remain silent on the matter.